Thursday, April 17, 2014

Nature Biotechnology

Complete Humanization of the Mouse Immunoglobulin Loci Enables Efficient Therapeutic Antibody Discovery.
Lee, E.-Chiang, Qi Liang, Hanif Ali, Luke Bayliss, Alastair Beasley, Tara Bloomfield-Gerdes, Laura Bonoli, et al.
Nature Biotechnology 32 (4): 356–63.

Nature Nanotechnology

All-Water-Based Electron-Beam Lithography Using Silk as a Resist.
Kim, Sunghwan, Benedetto Marelli, Mark A. Brenckle, Alexander N. Mitropoulos, Eun-Seok Gil, Konstantinos Tsioris, Hu Tao, David L. Kaplan, and Fiorenzo G. Omenetto.
Nature Nanotechnology 9 (4): 306–10.


Rescuing US Biomedical Research from Its Systemic Flaws.
Alberts, Bruce, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus.
Proceedings of the National Academy of Sciences, April, 201404402. doi:10.1073/pnas.1404402111.

Combined Hydrogels That Switch Human Pluripotent Stem Cells from Self-Renewal to Differentiation.
Dixon, James E., Disheet A. Shah, Catherine Rogers, Stephen Hall, Nicola Weston, Christopher D. J. Parmenter, Donal McNally, Chris Denning, and Kevin M. Shakesheff.
Proceedings of the National Academy of Sciences 111 (15): 5580–85. doi:10.1073/pnas.1319685111.

Kinetic Evidence for a Two-Stage Mechanism of Protein Denaturation by Guanidinium Chloride.
Jha, Santosh Kumar, and Susan Marqusee.
Proceedings of the National Academy of Sciences 111 (13): 4856–61. doi:10.1073/pnas.1315453111.

Shape Matters in Protein Mobility within Membranes.
Quemeneur, François, Jon K. Sigurdsson, Marianne Renner, Paul J. Atzberger, Patricia Bassereau, and David Lacoste. 2014.
Proceedings of the National Academy of Sciences 111 (14): 5083–87. doi:10.1073/pnas.1321054111.

Imaging Bacterial Peptidoglycan with near-Infrared Fluorogenic Azide Probes.
Shieh, Peyton, M. Sloan Siegrist, Andrew J. Cullen, and Carolyn R. Bertozzi.
Proceedings of the National Academy of Sciences 111 (15): 5456–61. doi:10.1073/pnas.1322727111.

Single-Molecule Spectroscopy Reveals Polymer Effects of Disordered Proteins in Crowded Environments.
Soranno, Andrea, Iwo Koenig, Madeleine B. Borgia, Hagen Hofmann, Franziska Zosel, Daniel Nettels, and Benjamin Schuler.
Proceedings of the National Academy of Sciences 111 (13): 4874–79. doi:10.1073/pnas.1322611111.

Wednesday, March 12, 2014

Molecular Therapy, Volume 22, Issue 3

A Hitchhiker’s Guide to the Blood–brain Barrier: In Trans Delivery of a Therapeutic Enzyme

Mark S Sands
Mol Ther 22: 483-484; doi:10.1038/mt.2014.12

Parkinson’s Disease Gene Therapy: Success by Design Meets Failure by Efficacy MTOpen
Raymond T Bartus, Marc S Weinberg and R. Jude Samulski
Mol Ther 22: 487-497; advance online publication, January 21, 2014; doi:10.1038/mt.2013.281

Targeted Drug Delivery to Intestinal Macrophages by Bioactive Nanovesicles Released from Grapefruit
Baomei Wang, Xiaoying Zhuang, Zhong-Bin Deng, Hong Jiang, Jingyao Mu, Qilong Wang, Xiaoyu Xiang, Haixun Guo, Lifeng Zhang, Gerald Dryden, Jun Yan, Donald Miller and Huang-Ge Zhang
Mol Ther 22: 522-534; advance online publication, January 14, 2014; doi:10.1038/mt.2013.190

Broad Therapeutic Benefit After RNAi Expression Vector Delivery to Deep Cerebellar Nuclei: Implications for Spinocerebellar Ataxia Type 1 Therapy
Megan S Keiser, Ryan L Boudreau and Beverly L Davidson
Mol Ther 22: 588-595; advance online publication, January 14, 2014; doi:10.1038/mt.2013.279

Molecular Therapy, Volume 22, Issue 2

Discovery of siRNA Lipid Nanoparticles to Transfect Suspension Leukemia Cells and Provide In Vivo Delivery Capability
Wei He, Michael J Bennett, Leopoldo Luistro, Daisy Carvajal, Thomas Nevins, Melissa Smith, Gaurav Tyagi, James Cai, Xin Wei, Tai-An Lin, David C Heimbrook, Kathryn Packman and John F Boylan
Mol Ther 22: 359-370; advance online publication, October 1, 2013; doi:10.1038/mt.2013.210

Angewandte Chemie, Volumen 53, Issue 11, Pages 2779–3032

No relevant articles.

Angewandte Chemie, Volume 53, Issue 10, Pages 2511–2775

Solid-Phase Incorporation of an ATRP Initiator for Polymer–DNA Biohybrids (pages 2739–2744)Saadyah E. Averick, Sourav K. Dey, Debasish Grahacharya, Krzysztof Matyjaszewski and Subha R. Das

Angewandte Chemie, Volume 53, Issue 9, Pages 2253–2507

Angewandte Chemie, Volume 53, Issue 8, Pages 2005–2249

No relevant articles.

Angewandte Chemie, Volume 53, Issue 7, Pages 1711–2001

Integrated Antimicrobial and Nonfouling Zwitterionic Polymers (pages 1746–1754)Luo Mi and Prof. Shaoyi Jiang
Article first published online: 20 JAN 2014 | DOI: 10.1002/anie.201304060

Biomimetic RNA-Silencing Nanocomplexes: Overcoming Multidrug Resistance in Cancer Cells (pages 1997–2001)Dr. Zhongliang Wang, Dr. Zhe Wang, Dr. Dingbin Liu, Dr. Xuefeng Yan, Prof. Fu Wang, Prof. Gang Niu, Prof. Min Yang and Prof. Xiaoyuan Chen

Angewandte Chemie, Volume 53, Issue 6, Pages 1451–1708

No relevant articles.

Angewandte Chemie, Volume 53, Issue 5, Pages 1169–1447

No relevant articles.

Angewandte Chemie, Volume 53, Issue 4, Pages 893–1166

No relevant articles.

Journal of the American Chemical Society, Volume 136, Issue 9, Pages 3321-3712

pp 3439–3455

Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

pp 3664–3672

Journal of the American Chemical Society, Volume 136, Issue 8, Pages 2929-3320

Macromolecular Metallurgy of Binary Mesocrystals via Designed Multiblock Terpolymers

pp 2974–2977

Controlling a Polymer Adhesive Using Light and a Molecular Switch

pp 3024–3027

Do π-Conjugative Effects Facilitate SN2 Reactions?

pp 3118–3126

Journal of the American Chemical Society, Volume 136, Issue 7, Pages 2681-2928

No relevant articles.

Journal of the American Chemical Society, Volume 136, Issue 6, Pages 2177-2680

Photopharmacology: Beyond Proof of Principle

pp 2178–2191

Reversible Anion-Induced Cross-Linking of Well-Defined Calix[4]pyrrole-Containing Copolymers

pp 2252–2255

Journal of the American Chemical Society, Volume 136, Issue 5, Pages 1681-2176

Design and Synthesis of Hydroxide Ion–Conductive Metal–Organic Frameworks Based on Salt Inclusion

pp 1702–1705
Publication Date (Web): January 14, 2014 (Communication)

Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

pp 1922–1929

Crystallization in Sequence-Defined Peptoid Diblock Copolymers Induced by Microphase Separation

pp 2070–2077
Publication Date (Web): January 15, 2014 (Article)

Anion−π Catalysis

pp 2101–2111
Publication Date (Web): January 23, 2014 (Article)

Journal of the American Chemical Society, Volume 136, Issue 4, Pages 1157-1680

No relevant articles

Tuesday, March 11, 2014

Nature Nanotechnology

DNA Assembly of Nanoparticle Superstructures for Controlled Biological Delivery and Elimination
Chou, Leo Y. T., Kyryl Zagorovsky, and Warren C. W. Chan
Nature Nanotechnology 9 (2): 148–55.

Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice
Pu, Kanyi, Adam J. Shuhendler, Jesse V. Jokerst, Jianguo Mei, Sanjiv S. Gambhir, Zhenan Bao, and Jianghong Rao
Nature Nanotechnology 9 (3): 233–39.

Prevention of Vascular Inflammation by Nanoparticle Targeting of Adherent Neutrophils
Wang, Zhenjia, Jing Li, Jaehyung Cho, and Asrar B. Malik
Nature Nanotechnology 9 (3): 204–10.

Multi-Resolution 3D Visualization of the Early Stages of Cellular Uptake of Peptide-Coated Nanoparticles
Welsher, Kevin, and Haw Yang
Nature Nanotechnology 9 (3): 198–203.

Nature Biotechnology

Beyond Model Antigens: High-Dimensional Methods for the Analysis of Antigen-Specific T Cells
Newell, Evan W., and Mark M. Davis
Nature Biotechnology 32 (2): 149–57.


In Vivo Discovery of Immunotherapy Targets in the Tumour Microenvironment
Zhou, Penghui, Donald R. Shaffer, Diana A. Alvarez Arias, Yukoh Nakazaki, Wouter Pos, Alexis J. Torres, Viviana Cremasco, et al.
Nature 506 (7486): 52–57.


Functional Truncated Membrane Pores
Stoddart, David, Mariam Ayub, Lajos Höfler, Pinky Raychaudhuri, Jochen W. Klingelhoefer, Giovanni Maglia, Andrew Heron, and Hagan Bayley
Proceedings of the National Academy of Sciences 111 (7): 2425–30.

Differential Uptake of Nanoparticles by Endothelial Cells through Polyelectrolytes with Affinity for Caveolae
Voigt, Julia, Jon Christensen, and V. Prasad Shastri
Proceedings of the National Academy of Sciences 111 (8): 2942–47.

Point-of-Care Diagnostics for Noncommunicable Diseases Using Synthetic Urinary Biomarkers and Paper Microfluidics
Warren, Andrew D., Gabriel A. Kwong, David K. Wood, Kevin Y. Lin, and Sangeeta N. Bhatia
Proceedings of the National Academy of Sciences 111 (10): 3671–76.

Journal of Polymer Science Part A: Polymer Chemistry

Nanocomposites based on crosslinked polyacrylic latex/silver nanoparticles for waterborne high-performance antibacterial coatings
Onur Yilmaz, Mikko Karesoja, A.Candas Adiguzel, Gokhan Zengin, Heikki Tenhu

Reversible crosslinking and decrosslinking of polymers containing alcohol moiety using an acyclic bifunctional vicinal triketone
Morio Yonekawa, Yoshio Furusho, Toshikazu Takata, Takeshi Endo

Polymer Chemistry

Ring-opening metathesis polymerization of 8-membered cyclic olefins
Henry Martinez, Ning Ren, Megan E. Mattaa and Marc A. Hillmyer

Low-temperature crosslinking of anion exchange membranes
Lizhu Wang and Michael A. Hickner

Multivalent polymer–Au nanocomposites with cationic surfaces displaying enhanced antimicrobial activity
Lin Mei, Xinge Zhang, Yanan Wang, Wei Zhang, Zhentan Lu, Yuting Luo, Yu Zhaoa and Chaoxing Li  

New dialkoxyamine-trithiocarbonate for the synthesis of multiblock copolymers through in tandem RAFT/NMP
Claude St Thomas, Hortensia Maldonado-Textle, Judith N. Cabello-Romero,   Javier Macossay, Xujun Zhang, Nuria Esturau-Escofetc and Ramiro Guerrero-Santos

Functional films from unsaturated poly(macrolactones) by thiol–ene cross-linking and functionalisation
Zeliha Ates and Andreas Heise

Introducing the Ugi reaction into polymer chemistry as a green click reaction to prepare middle-functional block copolymers
Bin Yang, Yuan Zhao, Changkui Fu, Chongyu Zhu, Yaling Zhang, Shiqi Wang,   Yen Weia and Lei Tao

Supramolecular polymer gels with potential model-network structure
Torsten Rossow and Sebastian Seiffert

Advanced Materials

High Capacity, Easy Release Adhesives From Renewable Materials
Michael D. Bartlett, Alfred J. Crosby

Enzymatic Polymerization of High Molecular Weight DNA Amphiphiles That Self-Assemble into Star-Like Micelles.
Lei Tang, Vinalia Tjong, Nan Li, Yaroslava G. Yingling, Ashutosh Chilkoti, Stefan Zauscher

Bulk Interpenetration Network of Thermoelectric Polymer in Insulating Supporting Matrix
Guanghao Lu, Laju Bu, Sijun Li, Xiaoniu Yang

Chemical Communications

Redox-active conjugated microporous polymers: a new organic platform for highly efficient energy storage
Fei Xu, Xiong Chen, Zhiwei Tang, Dingcai Wu, Ruowen Fub and Donglin Jiang

Nature Chemistry, vol 6, issue 3

Christophe Detrembleur, Precision design of ethylene- and polar-monomer-based copolymers by organometallic-mediated radical polymerization.

Masayuki Takeuchi, Living supramolecular polymerization realized through a biomimetic approach.

Nature Chemistry, vol 6 issue 2

Edward Tate et al, Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Kimoon Kim et al, Hollow nanotubular toroidal polymer microrings.

Chem Soc Revs, vol. 43, issues 6,7

Darren Johnson et al, Transmetalation of self-assembled,supramolecular complexes.

Issue 7 is ALL about nucleation and growth of crystals.

Synthetic ion transporters: Pore formation in bilayers via coupled activity of non-spanning cobalt-cage amphiphiles
Lorale J. Lalgee, Lebert Grierson, Richard A. Fairman, Gina E. Jaggernauth, Albert Schulte, Roland Benz, Mathias Winterhalter

An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo
Praveen Papareddy, Martina Kalle, Shalini Singh, Matthias Mörgelin, Artur Schmidtchen, Martin Malmsten

Cell-free synthesis of membrane proteins: Tailored cell models out of microsomes
Susanne F. Fenz, Rita Sachse, Thomas Schmidt, Stefan Kubick

Structure–activity relationships of the antimicrobial peptide gramicidin S and its analogs: Aqueous solubility, self-association, conformation, antimicrobial activity and interaction with model lipid membranes
Thomas Abraham, Elmar J. Prenner, Ruthven N.A.H. Lewis, Colin T. Mant, Sandro Keller, Robert S. Hodges, Ronald N. McElhaney

Advanced Drug Delivery

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
Nicolas Bertrand, Jun Wu, Xiaoyang Xu, Nazila Kamaly, Omid C. Farokhzad

Nanopreparations for organelle-specific delivery in cancer
Swati Biswas, Vladimir P. Torchilin

Stimuli-responsive cross-linked micelles for on-demand drug delivery against cancers
Yuanpei Li, Kai Xiao, Wei Zhu, Wenbin Deng, Kit S. Lam

Liposomal siRNA nanocarriers for cancer therapy
Bulent Ozpolat, Anil K. Sood, Gabriel Lopez-Berestein

Bioconjugate Chemistry

Site-Specific Antibody–Drug Conjugation through Glycoengineering
Qun Zhou, James E. Stefano, Charlene Manning, Josephine Kyazike, Bo Chen, Diego A. Gianolio, Anna Park, Michelle Busch, Julie Bird, Xiaoyang Zheng, Helene Simonds-Mannes, Jennifer Kim, Rick C. Gregory, Robert J. Miller, William H. Brondyk, Pradeep K. Dhal, and Clark Q. Pan
DOI: 10.1021/bc400505q

Red Emitting Neutral Fluorescent Glycoconjugates for Membrane Optical Imaging
Sebastien Redon, Julien Massin, Sandrine Pouvreau, Evelien De Meulenaere, Koen Clays, Yves Queneau, Chantal Andraud, Agnes Girard-Egrot, Yann Bretonnière, and Stéphane Chambert
DOI: 10.1021/bc500047r

Monday, March 10, 2014

Soft Matter Vol 10 Issue 4-

Free energy change for insertion of charged, monolayer-protected nanoparticles into lipid bilayers

Effect of solvent hydrophobicity on gelation kinetics and phase diagram of gelatin ionogels

Mesoscale modeling of hydrated morphologies of sulfonated polysulfone ionomers

Protein cluster formation in aqueous solution in the presence of multivalent metal ions – a light scattering study

Scaling behavior and local structure of ion aggregates in single-ion conductors

Electro-actuated hydrogel walkers with dual responsive legs

Modeling polymer grafted nanoparticle networks reinforced by high-strength chains (Check out the movies!)

Journal of Power Sources Vol 248-250

Crosslinked poly(vinylbenzyl chloride) with a macromolecular crosslinker for anion exchange membrane fuel cells

Chem Soc Revs, vol 43, issues 4,5

Note: special issue on single molecule studies.

Johan Hofkens et al, Single molecule methods for the study of catalysis: from enzymes to heterogeneous catalysts.

G. Ulrich Nienhaus et al, Fluorescent proteins for live-cell imaging with super-resolution.

Colin Raston et al, Controlling nanomaterial synthesis, chemicalreactions and self assembly in dynamic thin films.

Anton Amann, Assessment, origin, and implementation of breathvolatile cancer markers.

Journal of the American Chemical Society, Volume 136, Issue 3, Pages 821-1156

In Vivo Targeting of Hydrogen Peroxide by Activatable Cell-Penetrating Peptides

pp 874–877
Publication Date (Web): December 30, 2013 (Communication)
pp 1116–1124
Publication Date (Web): January 8, 2014 (Article)

Organic Letters, vol 16, issue 5

Laura Cipolla et al, Dendron Synthesis and Carbohydrate Immobilization on a Biomaterial Surface by a Double-Click Reaction.

Nathan McClenaghan et al, Formation of a Hydrogen-Bonded Barbiturate [2]-Rotaxane.

Hans-Jorg Roth et al, Cyclic Carbo-Isosteric Depsipeptides and Peptides as a Novel Class of Peptidomimetics.

ChemBioChem, Volume 15, Issue 4

A Light-Activated Metal Complex Targets both DNA and RNA in a Fluorescent in Vitro Transcription and Translation Assay (pages 507–511)
Dr. David K. Heidary and Dr. Edith C. Glazer

Organic Letters, vol 16, issues 3, 4

Xiang Gao et al, Reductive Benzylation of C60 Imidazoline with a Bulky Addend.

Chi-Meng Che et al, Ruthenium Porphyrin Catalyzed Three-Component Reaction of Diazo Compounds, Nitrosoarenes, and Alkynes: An Efficient Approach to Multifunctionalized Aziridines.

ACS Chemical Biology, Volume 9, Issue 2

Molecular Vehicles for Mitochondrial Chemical Biology and Drug Delivery (review)

Journal of Controlled Release

Vol. 178

Systemic siRNA delivery to a spontaneous pancreatic tumor model in transgenic mice by PEGylated calcium phosphate hybrid micelles

Frederico Pittella, Horacio Cabral, Yoshinori Maeda, Peng Mi, Sumiyo Watanabe, Hiroyasu Takemoto, Hyun Jin Kim, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka; Pages 18-24

Intracellular delivery of functionally active proteins using self-assembling pyridylthiourea-polyethylenimine

Viktoriia Postupalenko, Annie-Paule Sibler, Dominique Desplancq, Yves Nominé, Danièle Spehner, Patrick Schultz, Etienne Weiss, Guy Zuber; Pages 86-94

Vol. 177

Self-assembled peptide nanoparticles as tumor microenvironment activatable probes for tumor targeting and imaging

Ying Zhao, Tianjiao Ji, Hai Wang, Suping Li, Yuliang Zhao, Guangjun Nie; Pages 11-19

Rapid and serum-insensitive endocytotic delivery of proteins using biotinylated polymers attached via multivalent hydrophobic anchors

Kyohei Tobinaga, Cuicui Li, Masafumi Takeo, Masayoshi Matsuda, Hiroko Nagai, Takuro Niidome, Tatsuhiro Yamamoto, Akihiro Kishimura, Takeshi Mori, Yoshiki Katayama; Pages 27-33

Bio-responsive delivery of tissue plasminogen activator for localized thrombolysis

Shahriar Absar, Young M. Kwon, Fakhrul Ahsan; Pages 42-50

Vol. 176

Cell-penetrating peptides meditated encapsulation of protein therapeutics into intact red blood cells and its application 

Review ArticleHuining He, Junxiao Ye, Yinsong Wang, Quan Liu, Hee Sun Chung, Young Min Kwon, Meong Cheol Shin, Kyuri Lee, Victor C. Yang; Pages 123-132

Chitosan nanoparticles for siRNA delivery: Optimizing formulation to increase stability and efficiency

H. Ragelle, R. Riva, G. Vandermeulen, B. Naeye, V. Pourcelle, C.S. Le Duff, C. D'Haese, B. Nysten, K. Braeckmans, S.C. De Smedt, C. Jérôme, V. Préa; Pages 54-63

Enhanced endosomal/lysosomal escape by distearoyl phosphoethanolamine-polycarboxybetaine lipid for systemic delivery of siRNA

Yan Li, Qiang Cheng, Qian Jiang, Yuanyu Huang, Hongmei Liu, Yuliang Zhao, Weipeng Cao, Guanghui Ma, Fengying Dai, Xingjie Liang, Zicai Liang, Xin Zhang; Pages 104-114

Chem EJ, vol 20 issues 9-11

Jinhui Luo, Jan Pieter Abrahams, Cyclic Peptides as Inhibitors of Amyloid Fibrillation.

Gilles Gasser et al, A Deadly Organometallic Luminescent Probe: Anticancer Activity