Science, VOL 319, ISSUE 5871, PAGES 1715-1882, 28 MARCH 2008

News Focus
SCIENCE AND COMMERCE: Science by the Masses
J. Travis
pg. 1750-1752

Books
SCIENCE AND THE ARTS: Another Approach to Consilience
J. Labinger
pg. 1763.

Perspectives
MATERIALS SCIENCE: Multitasking in Tissues and Materials
P. B. Messersmith
pg. 1767-1768.

Reports
Self-Assembly of Large and Small Molecules into Hierarchically Ordered Sacs and Membranes
R. M. Capito, H. S. Azevedo, Y. S. Velichko, A. Mata, and S. I. Stupp
pg. 1812-1816.

The Transition from Stiff to Compliant Materials in Squid Beaks
A. Miserez, T. Schneberk, C. Sun, F. W. Zok, and J. H. Waite
pg. 1816-1819.

organic letters, 2008, 10, 1481

Visible Near-Infrared Chemosensor for Mercury Ion


Mei Zhu, Mingjian Yuan, Xiaofeng Liu, Jialiang Xu, Jing Lv, Changshui Huang,
Huibiao Liu, Yuliang Li,* Shu Wang, and Daoben Zhu

Organic Letters, 2008, 10, 1469

A New Type of Soft Vesicle-Forming Molecule: An Amino Acid Derived Guanidiniocarbonyl Pyrrole Carboxylate Zwitterion

Thomas Rehm,† Vladimir Stepanenko,† Xin Zhang,† Frank Wu1rthner,†
Franziska Gro1hn,‡ Katja Klein,‡ and Carsten Schmuck*,†

Organic Letters, 2008, 10, 1275

Chiral Induction in Phenanthroline-Derived Oligoamide Foldamers: An Acid- and Base-Controllable Switch in Helical Molecular Strands


Hai-Yu Hu,†,‡ Jun-Feng Xiang,† Yong Yang,† and Chuan-Feng Chen*,†

Nano Letters, Vol. 8, Iss. 2, February 2008.

Wide Varieties of Cationic Nanoparticles Induce Defects in Supported Lipid Bilayers

Pascale R. Leroueil, Stephanie A. Berry, Kristen Duthie, Gang Han, Vincent M. Rotello, Daniel Q. McNerny, James R. Baker, Jr., Bradford G. Orr, and Mark M. Banaszak Holl, pp 420 - 424.

Nature, Vol. 451, Number 7184.

Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

Yu He, Tao Ye, Min Su, Chuan Zhang, Alexander E. Ribbe, Wen Jiang & Chengde Mao, p198.

Nature, Vol. 452, Number 7183.

Massachusetts gears up to boost cash for life sciences, p15.

Multi-membrane hydrogels

Sébastien Ladet, Laurent David & Alain Domard, p76.

Nature, Vol. 451, Number 7181.

Self-healing and thermoreversible rubber from supramolecular assembly

Philippe Cordier, François Tournilhac, Corinne Soulié-Ziakovic & Ludwik Leibler, p977.

Nature, Vol. 451, Number 7179.

Working double-blind - Should there be author anonymity in peer review?

P605.

Building better batteries

M. Armand & J.-M. Tarascon, p652.

An updatable holographic three-dimensional display

Sava Tay, P.-A. Blanche, R. Voorakaranam, A. V. Tunç, W. Lin, S. Rokutanda, T. Gu, D. Flores, P. Wang, G. Li, P. St Hilaire, J. Thomas, R. A. Norwood, M. Yamamoto & N. Peyghambarian, p694.

Science, VOL 319, ISSUE 5869, PAGES 1453-1551

Special Features:
SCIENCE CAREERS: Playing Well With Industry
E. Pain
pg. 1548-1551.

SCIENCE CAREERS: Business Financing for Your Research
A. Kotok
pg. 1549.

SCIENCE CAREERS: Finding Industry Funding
S. Carpenter
pg. 1550-1551.

News of the Week:
BIOMEDICAL RESEARCH: $300 Million in Private Money for New Investigators
J. Kaiser
pg. 1469.

SCIENTIFIC WORKPLACE: Indian Government Offers Helping Hand to Women Scientists
P. Bagla
pg. 1470b.

News Focus:
GRADUATE TRAINING: NSF Fellowships Called Powerful Tool for Building the Pipeline
J. Mervis
pg. 1477.

Perspectives
MATERIALS SCIENCE: The New Diamond Age?
P. W. May
pg. 1490-1491.

Reports
Synthesis of Macrocyclic Copolymer Brushes and Their Self-Assembly into Supramolecular Tubes
M. Schappacher, and A. Deffieux
pg. 1512-1515.

Nature Reviews Microbiology, Vol 6, No. 3 (March 2008)

Membrane lipid homeostasis in bacteria

Yong-Mei Zhang & Charles O. Rock

pp. 222-234

Antimicrobial Agents and Chemotherapy, Vol 52, Iss. 3, (March 2008)

Microbicidal Properties and Cytocidal Selectivity of Rhesus Macaque Theta Defensins
Dat Tran, Patti Tran, Kevin Roberts, George Ösapay, Justin Schaal, Andre Ouellette, and Michael E. Selsted
pp. 944-953

Antimicrobial Activity of Omiganan Pentahydrochloride against Contemporary Fungal Pathogens Responsible for Catheter-Associated Infections
Thomas R. Fritsche, Paul R. Rhomberg, Helio S. Sader, and Ronald N. Jones
pp. 1187-1189

Biomacromolecules, Vol 9, Iss 3 (March 2008)

Stability and Nonfouling Properties of Poly(poly(ethylene glycol) methacrylate) Brushes under Cell Culture Conditions
Stefano Tugulu and Harm-Anton Klok
pp 906 - 912

Biomaterials, Volume 29, Issue 14, May 2008

Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses

Jinah Kim, Anthony Conway and Anuj Chauha

Abstract

We developed extended wear silicone hydrogel soft contact lenses that deliver ophthalmic drugs for an extended period of time ranging from weeks to months. Silicone hydrogels comprising of N,N-dimethylacrylamide, 3-methacryloxypropyltris(trimethylsiloxy)silane, bis-alpha,omega-(methacryloxypropyl) polydimethylsiloxane, 1-vinyl-2-pyrrolidone, and ethylene glycol dimethacrylate were prepared with varying ratios of monomers and transport of three different ophthalmic drugs, timolol, dexamethasone, and dexamethasone 21-acetate was explored. All the silicone hydrogels of 0.1 mm thickness exhibit diffusion limited transport and extended release varying 20 days up to more than three months depending on the compositions of hydrophobic and hydrophilic components of silicone hydrogels. Also, there are multiple time scales in transport of at least certain molecules, which is perhaps due to the complex microstructure of these gels. The mechanical and physical properties of lenses such as ion permeability, equilibrium water content, transparency, and surface contact angles of some of the gels are suitable for contact lens application.

Biomaterials, Volume 29, Issue 14, May 2008, Pages 2164-2172

Biodegradable thermogelling poly(ester urethane)s consisting of poly(lactic acid) – Thermodynamics of micellization and hydrolytic degradationXian Jun Loh, Yun Xuan Tan, Ziyun Li, Lin Shin Teo, Suat Hong Goh and Jun L

Biomaterials

Mechanically strong double network photocrosslinked hydrogels from N,N-dimethylacrylamide and glycidyl methacrylated hyaluronan

Pages 2153-2163
Lihui Weng, Andrew Gouldstone, Yuhong Wu and Weiliam Chen



Fig. 1. Illustration of the living radical feature of CLiPP system. (A) The CLiPP photopolymer system forms a crosslinked polymer network upon exposure to UV light, incorporating DTC groups as polymer chain end-caps. DTC groups remain on the polymer surface. (B) Upon subsequent exposure to UV light, DTC and carbon radicals are reformed. (C) Carbon radicals can propagate through other vinyl groups. (D) The DTC radicals then re-cap the new carbon radical. Steps (A) through (D) continue until UV light is terminated or all of the materials are consumed. This process enables facile modification of polymer surfaces with brush grafted functional materials (E), or with crosslinkable materials (F).

Vol. 41, No. 2 February 2008 315-326 ACCOUNTS OF CHEMICAL RESEARCH

Enzymatic Hydrogelation of Small Molecules
ZHIMOU YANG, GAOLIN LIANG, AND BING XU


In this Account, we discuss the use of enzymes to trigger and control the self-assembly of small molecules for hydrogelation,which takes place in vitro or in vivo, extra- or intracellularly. Using phosphatase, thermolysin, -lactamase, and phosphatase/kinase as examples, we illustrate the design and application of enzyme-catalyzed or -regulated formation of supramolecular hydrogels that offer a new strategy for detecting the activity of enzymes, screening for enzyme inhibitors,
typing bacteria, drug delivery systems, and controlling the fate of cells. Since the expression and distribution of enzymes differ by the types and states of cells, tissues, and organs, using an enzymatic reaction to convert precursors into hydrogelators that self-assemble into nanofibers as the matrices of the hydrogel, one can control the delivery, function, and response of a hydrogel according to a specific biological condition or environment, thus providing an accessible route to create sophisticated materials for biomedicine. Particularly, intracellular enzymatic hydrogelation of small molecules offers a unique means for scientists to integrate molecular self-assembly with inherent enzymatic reactions inside cells for developing new biomaterials and therapeutics at the supramolecular level and improving the basic understanding of dynamic molecular selfassembly in water.

PNAS | February 19, 2008 | vol. 105 | no. 7 | 2307-2312

A biodegradable and biocompatible gecko-inspired tissue adhesive

Alborz Mahdavi, Lino Ferreira, Cathryn Sundback, Jason W. Nichol, Edwin P. Chan, David J. D. Carter, Chris J. Bettinger, Siamrut Patanavanich, Loice Chignozha, Eli Ben-Joseph, Alex Galakatos, Howard Pryor, Irina Pomerantseva, Peter T. Masiakos, William Faquin, Andreas Zumbuehl, Seungpyo Hong, Jeffrey Borenstein, Joseph Vacanti, Robert Langer, and Jeffrey M. Karp

PNAS | February 19, 2008 | vol. 105 | no. 7 | 2586-2591

Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers
Frank Gu, Liangfang Zhang, Benjamin A. Teply, Nina Mann, Andrew Wang,, Aleksandar F. Radovic-Moreno, Robert Langer, and Omid C. Farokhzad

Science, VOL 319, ISSUE 5867-8, PAGES 1157, 1414 Feb-Mar 2008

News of the Week
PEER REVIEW: NIH Urged to Focus on New Ideas, New Applicants
J. Kaiser (29 February 2008)
Science 319 (5867), 1169.

SCIENTIFIC MISCONDUCT: Chemist Found Responsible for Ethical Breaches
R. F. Service (29 February 2008)
Science 319 (5867), 1170b-1171b.

RESEARCH FUNDING: Philip Morris Pulls the Plug on Controversial Research Program
D. Grimm (29 February 2008)
Science 319 (5867), 1173a.

Perspectives
MATERIALS SCIENCE: New Materials at a GlanceM. J. Brett, and M. M. Hawkeye (29 February 2008)
Science 319 (5867), 1192-1193

Reports
Stimuli-Responsive Polymer Nanocomposites Inspired by the Sea Cucumber Dermis
J. R. Capadona, K. Shanmuganathan, D. J. Tyler, S. J. Rowan, and C. Weder (7 March 2008)
Science 319 (5868), 1370-1374.

Chemical Society Reviews

Catalytic methods for the destruction of chemical warfare agents under ambient conditions
Bryan M. Smith
Chem. Soc. Rev., 2008, 37, 470 - 478,

Chemistry - A European Journal

Self-Assembled Structures in Organogels of Amphiphilic Diblock Codendrimers
Miao Yang, Zijian Zhang, Fei Yuan, Wei Wang, Sandra Hess, Karen Lienkamp, Ingo Lieberwirth, Gerhard Wegner

JACS vol 130, no 9 (Mar 5, 2008)

.
Stoichiometric Functionalization of Gold Nanoparticles in Solution through a Free Radical Polymerization Approach
Christian Krüger, Seema Agarwal, and Andreas Greiner
pp 2710 - 2711


Sub-100 nm Patterning of Supported Bilayers by Nanoshaving Lithography
Jinjun Shi, Jixin Chen, and Paul S. Cremer
pp 2718 - 2719


A Templating Approach for Monodisperse Self-Assembled Organic Nanostructures
Steve R. Bull, Liam C. Palmer, Nathaniel J. Fry, Megan A. Greenfield, Benjamin W. Messmore, Thomas J. Meade, and Samuel I. Stupp
pp 2742 - 2743


Self-delivering Nanoemulsions for Dual Fluorine-19 MRI and Fluorescence Detection
Jelena M. Janjic, Mangala Srinivas, Deepak K.K. Kadayakkara, and Eric T. Ahrens
pp 2832 - 2841

JACS vol 130, no 8 (Feb 27, 2008)

.
Surface Patterning with Fluorescent Molecules Using Click Chemistry Directed by Scanning Electrochemical Microscopy
Sung-Yu Ku, Ken-Tsung Wong, and Allen J. Bard
pp 2392 - 2393

JACS vol 130 no 7 (Feb 20, 2008)

.
Lipid-Protein Nanoscale Bilayers: A Versatile Medium for NMR Investigations of Membrane Proteins and Membrane-Active Peptides
Ekaterina N. Lyukmanova, Zakhar O. Shenkarev, Alexander S. Paramonov, Alexander G. Sobol, Tatiana V. Ovchinnikova, Vladimir V. Chupin, Mikhail P. Kirpichnikov, Marcel J. J. Blommers, and Alexander S. Arseniev
pp 2140 - 214

chembiochem, 2008, 9, 634

A Novel Sensor Platform Based on Aptamer-Conjugated Polypyrrole Nanotubes for Label-Free Electrochemical Protein Detection


Hyeonseok Yoon,[a] June-Hyung Kim,[b] Nahum Lee,[c] Byung-Gee Kim,[c] and Jyongsik Jang*[a]

organic letters, 2008, 10, 897

Synthesis of a New Photoactive Nanovehicle: A Nanoworm

Takashi Sasaki and James M. Tour*

This time, they call it Nanoworm, instead of Nanocar.

Angewandte Chemie International Edition 06-2008 to 12-2008

Angewandte Chemie International Edition 6/2008

Highly Stable Giant Supramolecular Vesicles Composed of 2D Hydrogen-Bonded Sheet Structures of Guanosine Derivatives (p 1038-1041)
Isao Yoshikawa, Jun Sawayama, Koji Araki

Self-Organization of Electroactive Materials: A Head-to-Tail Donor-Acceptor Supramolecular Polymer (p 1094-1097)
Gustavo Fernández, Emilio M. Pérez, Luis Sánchez, Nazario Martín

Angewandte Chemie International Edition 7/2008

Nanofibers and Lyotropic Liquid Crystals from a Class of Self-Assembling -Peptides (p 1241-1244)
William C. Pomerantz, Virany M. Yuwono, Claire L. Pizzey, Jeffery D. Hartgerink, Nicholas L. Abbott, Samuel H. Gellman

Antibacterial and Hemolytic Activities of Pyridinium Polymers as a Function of the Spatial Relationship between the Positive Charge and the Pendant Alkyl Tail (p 1250-1254)
Varun Sambhy, Blake R. Peterson, Ayusman Sen

Virion-Mimicking Nanocapsules from pH-Controlled Hierarchical Self-Assembly for Gene Delivery (p 1260-1264)
Peisheng Xu, Shi-Yan Li, Qun Li, Edward A. Van Kirk, Jun Ren, William J. Murdoch, Zhaojie Zhang, Maciej Radosz, Youqing Shen

Vesicle Formation from Reactive Surfactants (p 1323-1325)
Helmut H. Zepik, Peter Walde, Takashi Ishikawa

Angewandte Chemie International Edition 8/2008

Tris(2,2-bipyridyl)ruthenium(II) with Branched Polyphenylene Shells: A Family of Charged Shape-Persistent Nanoparticles (p 1662-1667)
Monika C. Haberecht, Jan M. Schnorr, Ekaterina V. Andreitchenko, Christopher G. Clark Jr., Manfred Wagner, Klaus Müllen

Angewandte Chemie International Edition 10/2008

Polymer Vesicles Containing Small Vesicles within Interior Aqueous Compartments and pH-Responsive Transmembrane Channels (p 1875-1878)
Hsin-Cheng Chiu, Yue-Wen Lin, Yi-Fong Huang, Chih-Kai Chuang, Chorng-Shyan Chern

Angewandte Chemie International Edition 11/2008

Preparation of Nanostructures by Orthogonal Self-Assembly of Hydrogelators and Surfactants (p 2063-2066)
Aurelie Brizard, Marc Stuart, Kjeld van Bommel, Arianna Friggeri, Menno de Jong, Jan van Esch

Hierarchically Structured Microparticles Formed by Interfacial Instabilities of Emulsion Droplets Containing Amphiphilic Block Copolymers (p 2113-2116)
Jintao Zhu, Ryan C. Hayward

Angewandte Chemie International Edition 12/2008
pH-Responsive Supramolecular Nanovalves Based on Cucurbit[6]uril Pseudorotaxanes (p 2222-2226)
Sarah Angelos, Ying-Wei Yang, Kaushik Patel, J. Fraser Stoddart, Jeffrey I. Zink

Reversible Switching between Macrocyclic and Polymeric States by Morphological Control in a Constitutional Dynamic System (p 2240-2243)
Sébastien Ulrich, Jean-Marie Lehn

Macromol. Rapid Commun 5/2008

Macromol. Rapid Commun 5/2008

Control of the Dynamic Motion of a Gel Actuator Driven by the Belousov-Zhabotinsky Reaction (p 401-405)
Shingo Maeda, Yusuke Hara, Ryo Yoshida, Shuji Hashimoto

Peculiar Reptational Movements of Single Synthetic Polymer Chains on Substrate Observed by AFM (p 406-411)
Jiro Kumaki, Takehiro Kawauchi, Eiji Yashima

Macromol. Rapid Commun. 4/2008

Special Issue: Self-Assembly and Hierarchical Structure Formation of Macromolecules

Issue Edited by M. Antonietti, A. D. Schlüter

...have a look at this! Both editors are well-known in Germany, and most of the corresponding authors are young European polymer people who just started their own groups.

Macromol. Rapid Commun. 3/2008

Non-Ideal Polymerization Kinetics of a Cationic Double Charged Acryl Monomer and Solution Behavior of the Resulting Polyelectrolytes (p 252-257)
Ricardo Losada, Christine Wandrey

...the paper isn't particularly exciting, however the monomer is nice and commercially available!

Self-Assembly of Diblock Copolymers into Novel Snowflake-Shaped Aggregates Driven by Quadruple Hydrogen Bonding (p 258-263)
Yu Wang, Yu Cao, Yipeng Qiu, Liming Tang

Nice TEM images.

Journal of Polymer Science Part A: Polymer Chemistry, Vol.46 Iss. 6 (March 2008)

Self-assembly of supramolecular polymers into tunable helical structures
Ho-Joong Kim, Yong-Beom Lim, Myongsoo Lee
(p 1925-1935)

Solvent influence on the orthogonality of noncovalently functionalized terpolymers
Caroline Burd, Marcus Weck
(p 1936-1944)

Adv. Mater. 2008, 20, 867–877

Nanobiomaterials and Nanoanalysis: Opportunities for Improving the Science to
Benefit Biomedical Technologies

David W. Grainger and David G. Castner

Macromolecules 2008, 41, 1175-1183

Synthesis, Characterization, and Charge/Discharge Properties of
Polynorbornenes Carrying 2,2,6,6-Tetramethylpiperidine-1-oxy
Radicals at High Density

Toru Katsumata, Jinqing Qu, Masashi Shiotsuki, Masaharu Satoh, Jun Wada,
Jun Igarashi, Kenji Mizoguchi, and Toshio Masuda

Biochemistry 2008, 47

Biochemistry 2008, 47, 3051–3060
Small Changes in the Primary Structure of Transportan 10 Alter the Thermodynamics and Kinetics of its Interaction with Phospholipid Vesicles
Lindsay E. Yandek, Antje Pokorny, and Paulo F. F. Almeida






Biochemistry 2008, 47, 2841–2849
Melittin Interaction with Sulfated Cell Surface Sugars
Gabriela Klocek and Joachim Seelig

14 Grand Challenges for Engineering (Feb 15, 2008)

.


Press release at the AAAS meeting.

How many can be tackled with a Polymer Science background?