Biochimica et Biophysica Acta

Interaction of an artificial antimicrobial peptide with lipid membranes
Lanlan Yu, Lin Guo, Jeak Ling Ding, Bow Ho, Si-shen Feng, Jonathan Popplewell,
Marcus Swann , Thorsten Wohland
Biochimica et Biophysica Acta 1788 (2009) 333–344

Fluorescent sterols monitor cell penetrating peptide Pep-1 mediated uptake and
intracellular targeting of cargo protein in living cells
Anca D. Petrescu, Aude Vespa, Huan Huang, Avery L. McIntosh, Friedhelm Schroeder, Ann B. Kier
Biochimica et Biophysica Acta 1788 (2009) 425–441

Lipid domains in bacterial membranes and the action of antimicrobial agents
Richard M. Epand, Raquel F. Epand
Biochimica et Biophysica Acta 1788 (2009) 289–294

Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures
Gerald W. Feigenson
Biochimica et Biophysica Acta 1788 (2009) 47–52

JACS, Vol. 131, No. 6

A Tandem Approach to Photoactivated Olefin Metathesis: Combining a Photoacid Generator with an Acid Activated Catalyst

Benjamin K. Keitz and Robert H. Grubbs

Single Conical Nanopores Displaying pH-Tunable Rectifying Characteristics. Manipulating Ionic Transport With Zwitterionic Polymer Brushes

Basit Yameen, Mubarak Ali, Reinhard Neumann, Wolfgang Ensinger, Wolfgang Knoll and Omar Azzaroni

High Lipophilicity of Perfluoroalkyl Carboxylate and Sulfonate: Implications for Their Membrane Permeability

Ping Jing, Patrick J. Rodgers and Shigeru Amemiya

JACS, Vol. 130, No. 7

In Situ Preparation and Modification of Supported Lipid Layers by Lipid Transfer from Vesicles Studied by QCM-D and TOF-SIMS

Angelika Kunze, Peter Sjovall, Bengt Kasemo and Sofia Svedhem

Catechols as Membrane Anion Transporters

Sofya Kostina Berezin and Jeffery T. Davis

Highly Uniaxial Orientation in Oligo(p-phenylenevinylene) Films Induced During Wet-Coating Process

Takeshi Nishizawa, Hady Kesuma Lim, Keisuke Tajima and Kazuhito Hashimoto

A Light-Gated STOP−GO Molecular Shuttle

Ali Coskun, Douglas C. Friedman, Hao Li, Kaushik Patel, Hussam A. Khatib and J. Fraser Stoddart

ACS Nano, 2008, 2 (12), pp 2519–2525

Enzyme Nanorings

Tsui-Fen Chou†, Christopher So§, Brian R. White†, Jonathan C. T. Carlson†, Mehmet Sarikaya§ and Carston R. Wagner†‡*

We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins. The dimensions of the nanorings were found by static light scattering and atomic force microscopy studies to be dependent on the length and composition of the peptide linking the fusion proteins, ranging in size from 10 to 70 nm in diameter and 64 to 740 kDa. The catalytic efficiency of the nanorings was found to be dependent on ring size, thus suggesting that the arrangement of supermolecular assemblies of enzymes may be used to control their catalytic parameters.

ACS Nano, 2009, 3 (1), pp 234–240

Assembly and Functionalization of DNA−Polymer Microcapsules

Francesca Cavalieri†‡, Almar Postma†, Lillian Lee†and Frank Caruso†*

We report the synthesis and characterization of DNA-grafted poly(N-isopropylacrylamide) (PNIPAM) micelles, their assembly into multilayered thin films, and the subsequent generation and poly(ethylene glycol) (PEG) functionalization of DNA−PNIPAM microcapsules. Multilayer films were assembled by sequentially depositing DNA-grafted PNIPAM micelles containing the cDNA sequences polyA₃₀ or polyT₃₀ (i.e., PNIPAM-A₃₀ or PNIPAM-T₃₀). DNA−polymer microcapsules were obtained by the alternate deposition of PNIPAM-A₃₀ and PNIPAM-T₃₀ onto silica particles, followed by removal of the template core. Upon removal of the silica core particle, shrinkage of between 30 and 50% was observed for the microcapsules. The presence of PNIPAM within the DNA−polymer hybrid film reduces the permeability of the microcapsules to macrosolutes (e.g., dextran) compared with microcapsules made solely of DNA. The hydrophobic core of the DNA-grafted PNIPAM micelles was designed to contain alkyne “click” groups, which were exploited to covalently couple azide-bearing low-fouling PEG to the DNA−PNIPAM microcapsules. The combination of hydrophobic and reactive “click” nanodomains, along with the degradability of DNA, offers a multifunctional and versatile DNA−polymer capsule system that is envisioned to find applications in the controlled delivery of therapeutics.

ACS Nano, 2009, 3 (1), pp 16–20 REVIEW

Impact of Nanotechnology on Drug Delivery

Omid C. Farokhzad†‡* and Robert Langer‡§*

† Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 ‡ MIT−Harvard Center for Cancer Nanotechnology Excellence § Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale. In its strictest definition from the National Nanotechnology Initiative, nanotechnology refers to structures roughly in the 1−100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed by top-down or bottom-up engineering of individual components. Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics.

Nature materials volume 8 No 1 pg 15 REVIEW

Physical approaches to biomaterial design

Samir Mitragotri¹ & Joerg Lahann²

Abstract

The development of biomaterials for drug delivery, tissue engineering and medical diagnostics has traditionally been based on new chemistries. However, there is growing recognition that the physical as well as the chemical properties of materials can regulate biological responses. Here, we review this transition with regard to selected physical properties including size, shape, mechanical properties, surface texture and compartmentalization. In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties.

Nature materials volume 8 No 2 pg 151

Infection-mimicking materials to program dendritic cells in situ -pp151 - 158

Omar A. Ali, Nathaniel Huebsch, Lan Cao, Glenn Dranoff & David J. Mooney

doi:10.1038/nmat2357

Cancer vaccines developed so far typically rely on cell manipulation techniques in the laboratory followed by re-introduction of the cells into the patient. Now, a polymeric material is shown to program and control the trafficking of immune cellsin situ, resulting in specific and protective anti-tumour properties.

Nature materials volume 8 No 2 - pp144 - 150

Complex and hierarchical micelle architectures from diblock copolymers using living, crystallization-driven polymerizations -pp144 - 150

Torben Gädt, Nga Sze Ieong, Graeme Cambridge, Mitchell A. Winnik & Ian Manners

doi:10.1038/nmat2356

A synthetic tool that uses living polymerizations driven by epitaxial crystallization is shown to create a range of complex micelle architectures made from diblock copolymers. Platelet micelles act as initiators for the formation of scarf-like structures with micellar tassels of controlled length, grown from specific locations

nature materials volume 8 article 1

Polymer chain dynamics and glass transition in athermal polymer/nanoparticle mixtures -

Hyunjoon Oh & Peter F. Green

doi:10.1038/nmat2354

Tailoring the properties of polymer nanocomposites—polymers incorporating nanoparticles—is essential to develop biomedical, or even electronic, applications. It is now shown that accurate control of the nanoparticle concentration in nanocomposites prepared from athermal mixtures considerably varies the physical properties with respect to the host polymer.

chembiochem, 2008, 10,34

How Nature Morphs Peptide Scaffolds into Antibiotics


Elizabeth M. Nolan and Christopher T. Walsh*[a]

mini review

chembiochem, 2009, 10, 230

Design of Cell-Surface-Retained Polymers for Artificial Ligand Display


Ryosuke Kamitani,[b] Kenichi Niikura,*[a] Takaharu Okajima,[c] Yasutaka Matsuo,[a] and Kuniharu Ijiro*[a]

chembiochem, 2009, 10,428

Capsaicin: Tailored Chemical Defence Against Unwanted “Frugivores”


Birgit Schulze[b] and Dieter Spiteller*[a]

organic letters, 2008, 10,5373

Biased Helical Folding of Chiral Oligoindole Foldamers

Veluru Ramesh Naidu, Min Cheol Kim, Jae-min Suk, Ho-Joong
Kim, Myongsoo Lee, Eunji Sim, and Kyu-Sung Jeong

organic letters, 11, 613

A Guanidinium Ion-Based Anion- and Solvent Polarity-Controllable Molecular Switch

Tzu-Chiun Lin, Chien-Chen Lai, and Sheng-Hsien Chiu

organic letters, 2009, 11, 385

A Molecular Cage-Based [2]Rotaxane That Behaves as a Molecular Muscle

Chun-Ju Chuang, Wan-Sheung Li, Chien-Chen Lai, Yi-Hung
Liu, Shie-Ming Peng, Ito Chao, and Sheng-Hsien Chiu

organic letters, 2009, 11, 69-72

Efficient Construction of Oligocholate Foldamers via “Click” Chemistry and Their Tolerance of Structural Heterogeneity

Xingang Pan, and Yan Zhao

New foldamers

Advanced materials, 2008, 20: 1-6

Shaped Films of Ionotropic Hydrogels Fabricated Using Templates of Patterned Pater

By Paul J. Bracher, Malancha Gupta, and George M. Whitesides

Soft Matter, 2008, 4, 2486-2491

Volume transition in composite poly(NIPAM)-giant unilamellar vesicles

by Clement C. Campillo, Andre P. Schroder, Carlos M. Marques and Brigitte Pepin-Donat

advanced materials, 2008, 20: 1-14

Hydrogels for Soft Machines

by Paul Calvert

JACS, Vol. 130, No. 48

Redox-Responsive Gel-Sol/Sol-Gel Transition in Poly(acrylic acid) Aqueous Solution Containing Fe(III) Ions Switched by Light

Fei Peng, Guangzhao Li, Xinxing Liu, Shuizhu Wu, and Zhen Tong*

Science, 2008, 322, 1257

Antimicrobial Defense and Persistent Infection in Insects
Eleanor R. Haine, et al.

Rogue Insect Immunity

David S. Schneider and Moria C. Chambers

Adv. Funct. Mater. 2008, 18, 1–8

Supported Lipid Bilayer on Nanocrystalline Diamond: Dual Optical and Field-Effect Sensor for Membrane Disruption

Priscilla Kailian Ang, Kian Ping Loh, Thorsten Wohland,Milos Nesladek and Emile Van Hove

Organic letters, 2003, 5, 4241 and organic letters, 2003, 5, 105

High-Load, ROMP-Generated Oligomeric Bis-acid Chlorides: Design of Soluble and Insoluble Nucleophile Scavengers


Joel D. Moore, Robert J. Byrne, Punitha Vedantham, Daniel L. Flynn, and Paul R. Hanson



ROMP-Generated Oligomeric Sulfonyl Chlorides as Versatile Soluble Scavenging Agents


Joel D. Moore, Russell H. Herpel, Joy R. Lichtsinn, Daniel L. Flynn, and Paul R. Hanson


two useful reactions

Chem. Commun., 2008, 6126–6127

PEGylated silicon nanoparticles: synthesis and characterizationw


P. K. Sudeep, Zachariah Page and Todd Emrick*

Chem. Commun., 2008, 6446 - 6470

Controlled ring-opening polymerisation of cyclic esters: polymer blocks
in self-assembled nanostructures

Andrew P. Dove

Chem. Eur. J. 2008, 14, 10579 – 10584

Protein-Resistant Surfaces through Mild Dopamine Surface
Functionalization

Jean-Yves Wach,[a] Barbora Malisova,[b] Simone Bonazzi,[a] Samuele Tosatti,[b]
Marcus Textor,[b] Stefan Zrcher,[b] and Karl Gademann

Chem. Eur. J. 2008, 14, 10949 – 10957

Development of a Library of N-Substituted Maleimides for the Local
Functionalization of Linear Polymer Chains

Sebastian Pfeifer and Jean-FranÅois Lutz

Chem. Eur. J. 2008, 14, 11274 – 11282

Anion-Responsive Supramolecular Gels

Hiromitsu Maeda

Chem. Eur. J. 2008,

Comparison of Facially Amphiphilic versus Segregated Monomers in the
Design of Antibacterial Copolymers

Gregory J. Gabriel,[a] Janet A. Maegerlein,[a] Christopher F. Nelson,[b]
Jeffrey M. Dabkowski,[b] Tarik Eren,[a] Klaus Nsslein,[b] and Gregory N. Tew*

Acc. Chem. Res. Vol. 41, Iss. 11

Cross Coupling

Large review on Cross Coupling reactions: reagents, catalysts, Suzuki, Sonogashira, etc.

Nanoletters, Vol. 8, No. 12

In-Fiber Semiconductor Filament Arrays

D. S. Deng, N. D. Orf, A. F. Abouraddy, A. M. Stolyarov, J. D. Joannopoulos, H. A. Stone and Y. Fink, pp 4265–4269

Chem. Eur. J. 2008,

Anion–p Slides for Transmembrane Transport

Jiri Mareda and Stefan Matile

Chem. Soc. Rev., 2008, 37, 2699 - 2715

Supramolecular gelling agents: can they be designed?

Parthasarathi Dastidar

J. Mater. Chem., 2009, 19, 60 - 62

Photomobile polymer materials—various three-dimensional movements

Munenori Yamada, Mizuho Kondo, Ryo Miyasato, Yumiko Naka, Jun-ichi Mamiya, Motoi Kinoshita, Atsushi Shishido, Yanlei Yu, Christopher J. Barrettc and Tomiki Ikeda

J. Mater. Chem., 2009, 19, 34 - 45,

Advances in combinatorial and high-throughput screening of biofunctional
polymers for gene delivery, tissue engineering and anti-fouling coatings

J. Carson Meredith

Nature Materials

Unexpected power-law stress relaxation of entangled ring polymers

M. Kapnistos^1,2,8, M. Lang^3,4, D. Vlassopoulos^1,5, W. Pyckhout-Hintzen⁶, D. Richter⁶, D. Cho^7,8, T. Chang⁷ & M. Rubinstein³

ACS Nano

Surface Morphology Diagram for Cylinder-Forming Block Copolymer Thin Films

Xiaohua Zhang†, Brian C. Berry†, Kevin G. Yager†, Sangcheol Kim†, Ronald L. Jones†, Sushil Satija‡, Deanna L. Pickel§, Jack F. Douglas†* and Alamgir Karim†*

ACS Nano

PEGylated Gold Nanoparticles Conjugated to Monoclonal F19 Antibodies as Targeted Labeling Agents for Human Pancreatic Carcinoma Tissue

Abstract

In this study, we describe optical detection of antibody-conjugated nanoparticles bound to surgically resected human pancreatic cancer tissue. Gold nanoparticles stabilized by heterobifunctional polyethylene glycol (PEG) were prepared using ∼15 nm spherical gold cores and covalently coupled to F19 monoclonal antibodies. The heterobifunctional PEG ligands contain a dithiol group for stable anchoring onto the gold surface and a terminal carboxy group for coupling of antibodies to the outside of the PEG shell. The nanoparticle−antibody bioconjugates form highly stable dispersions and exhibit long-term resistance to agglomeration. This has been demonstrated by dynamic light scattering, size exclusion chromatography, and transmission electron microscopy. The nanoparticle bioconjugates were used to label tumor stroma in approximately 5 μm thick sections of resected human pancreatic adenocarcinoma. After rinsing away nonbound nanoparticles and fixation, the tissue samples were imaged by darkfield microscopy near the nanoparticle resonance scattering maximum (∼560 nm). The images display pronounced tissue features and suggest that this novel labeling method could provide for facile identification of cancer tissue. Tumor samples treated with gold nanoparticles conjugated to nonspecific control antibodies and noncancerous pancreatic tissue treated with mAb-F19-conjugated gold nanoparticles both exhibited correctly negative results and showed no tissue staining.

Biochimica et Biophysica Acta 1778 (2008) 2749–2756

pH-sensitive non-phospholipid vesicle and macrophage-like cells:
Binding, uptake and endocytotic pathway
L. Di Marzio, C. Marianecci , B. Cinque , M. Nazzarri , A.M. Cimini, L. Cristiano, M.G. Cifone,
F. Alhaique, M. Carafa

Organic & Biomolecular Chemistry, 2009, 7

Switchable electrostatic interactions between gold nanoparticles and coiled
coil peptides direct colloid assembly†
Sara C. Wagner, Meike Roskamp, Helmut Colfen, Christoph Bottcher, Sabine Schlecht* and Beate Koksch*

Very long-chain fatty tails for enhanced transfection†
Aleksandra Liberska, Asier Unciti-Broceta and Mark Bradley*

ACS Chem. Bio.

Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs
Artem Cherkasov, Kai Hilpert, Håvard Jenssen, Christopher D. Fjell, Matt Waldbrook, Sarah C. Mullaly, Rudolf Volkmer, and Robert E.W. Hancock

New journal chemistry, 2008, 32, 1850

Selected recent developments in organo-cobalt chemistry

Caroline J. Scheuermann ne´ e Taylor*a and Benjamin D. Wardb

mini review of Cobalt chemistry

Small, 2008, 4, 1711-1715

Photodynamic Thermoresponsive Nanocarbon-polymer Gel hybrids

by Eijiro Miyako, Hideya Nagata, Ken Hirano, and Takahiro Hirotsu

Advanced materials, 2008, 20: 1-5

Nanoporous Biodegradable Elastomers

by Ryan A. Hoshi, Saloni Behl, and Guillermo A. Ameer

Biochimica et Biophysica Acta 1778 (2008) 2487–2495

Cellular uptake and membrane-destabilising properties of α-peptide/β-peptoid
chimeras: lessons for the design of new cell-penetrating peptides
Camilla Foged, Henrik Franzyk, Shervin Bahrami, Sven Frokjaer, Jerzy W. Jaroszewski,
Hanne M. Nielsen, Christian A. Olsen

Biochemistry 2008, 47, 11070–11076

Using an Amino Acid Fluorescence Resonance Energy Transfer Pair To Probe Protein Unfolding: Application to the Villin Headpiece Subdomain and the LysM Domain
Julie M. Glasscock,‡ Yongjin Zhu,§ Pramit Chowdhury,§ Jia Tang,§ and Feng Gai*

JACS, Vol. 130, No. 45

Peptide-Based SAMs that Resist the Adsorption of Proteins
Rolf Chelmowski,† Stephan David Koster,‡ Andreas Kerstan,† Andreas Prekelt,† Christian Grunwald,§ Tobias Winkler,| Nils Metzler-Nolte,‡ Andreas Terfort,| and Christof Wo¨ ll*,†

Design of Polymeric Carriers for Cancer-Specific Gene Targeting: Utilization of Abnormal Protein Kinase Cr Activation in Cancer Cells
Jeong-Hun Kang, Daisuke Asai,§ Jong-Hwan Kim, Takeshi Mori, Riki Toita,
Tetsuro Tomiyama, Yoji Asami, Jun Oishi, Yuko T. Sato,Takuro Niidome,Byungdug Jun, Hideki Nakashima, and Yoshiki Katayama

Encapsulation Efficiency Measured on Single Small Unilamellar Vesicles
Brian Lohse, Pierre-Yves Bolinger, and Dimitrios Stamou

Anionic Amphiphilic Dendrimers as Antibacterial Agents
Steven R. Meyers, Frank S. Juhn, Aaron P. Griset, Nathanael R. Luman, and Mark W. Grinstaff*

Nernstian Adsorbate-like Bulk Layer of Organic Radical Polymers for High-Density Charge Storage Purposes
Kenichi Oyaizu, Yuko Ando, Hiroaki Konishi, and Hiroyuki Nishide

Langmuir, Vol 24, Iss 21, Nov 2008

Controlled Magnetic Nanofiber Hydrogels by Clustering Ferritin
Min Kyoon Shin, Sun I. Kim, Seon Jeong Kim, Sang Yoon Park, Young Hoon Hyun, YoungPak Lee, Kyung Eun Lee, Sung-Sik Han, Dong-Pyo Jang, Young-Bo Kim, Zang-Hee Cho, Insuk So, and Geoffrey M. Spinks
pp 12107 - 12111

Antifouling Properties of Poly(methyl methacrylate) Films Grafted with Poly(ethylene glycol) Monoacrylate Immersed in Seawater
O. Iguerb, C. Poleunis, F. Mazéas, C. Compère, and P. Bertrand
pp 12272 - 12281

How To Prevent the Loss of Surface Functionality Derived from Aminosilanes
Emily Asenath Smith and Wei Chen
pp 12405 - 12409

Diffusion of Macromolecules on Lipid Vesicles
W. T. Góźdź
pp 12458 - 12468

Langmuir, Vol 24, Iss 20, Oct 2008

Entrapping Desired Amounts of Actin Filaments and Molecular Motor Proteins in Giant Liposomes
Kingo Takiguchi, Ayako Yamada, Makiko Negishi, Yohko Tanaka-Takiguchi, and Kenichi Yoshikawa
pp 11323 - 11326

Particle Size Determination Using TEM: A Discussion of Image Acquisition and Analysis for the Novice Microscopist
William D. Pyrz and Douglas J. Buttrey
pp 11350 - 11360

Enhancing Amine Terminals in an Amine-Deprived Collagen Matrix
William H. C. Tiong, Gopinath Damodaran, Hemantkumar Naik, John L. Kelly, and Abhay Pandit
pp 11752 - 11761

Transmembrane Delivery of the Cell-Penetrating Peptide Conjugated Semiconductor Quantum Dots
Bo Chen, Qiaoling Liu, Yuliang Zhang, Li Xu, and Xiaohong Fang
pp 11866 - 11871