TEW GROUP LITERATURE

While nanocrystalline diamond is quickly becoming one of the most widely studied nanomaterials, achieving a large fraction of diamond nanoparticles in a polymer coating has been an unresolved problem. In this work, polymer nano- and microfibers containing high loadings of 5 nm diamond particles (up to 80 wt % in polyacrylonitrile and 40% in polyamide 11) have been demonstrated using electrospun nanofibers as a delivery vehicle. The electrospun nanofibers with a high load of nanodiamond in the polymers were fused into thin transparent films, which had high mechanical properties; an improvement of 4 times for the Young’s modulus and 2 times for the hardness was observed already at 20% nanodiamond in polyamide 11. These films can provide UV protection and scratch resistance to a variety of surfaces, especially in applications where a combination of mechanical, thermal, and dielectric properties is required.

ACS Nano article 1

A Mechanical Actuator Driven Electrochemically by Artificial Molecular Muscles

Abstract:

A microcantilever, coated with a monolayer of redox-controllable, bistable [3]rotaxane molecules (artificial molecular muscles), undergoes reversible deflections when subjected to alternating oxidizing and reducing electrochemical potentials. The microcantilever devices were prepared by precoating one surface with a gold film and allowing the palindromic [3]rotaxane molecules to adsorb selectively onto one side of the microcantilevers, utilizing thiol-gold chemistry. An electrochemical cell was employed in the experiments, and deflections were monitored both as a function of (i) the scan rate (≤20 mV s⁻¹) and (ii) the time for potential step experiments at oxidizing (>+0.4 V) and reducing (<+0.2 V) potentials. The different directions and magnitudes of the deflections for the microcantilevers, which were coated with artificial molecular muscles, were compared with (i) data from nominally bare microcantilevers precoated with gold and (ii) those coated with two types of control compounds, namely, dumbbell molecules to simulate the redox activity of the palindromic bistable [3]rotaxane molecules and inactive 1-dodecanethiol molecules. The comparisons demonstrate that the artificial molecular muscles are responsible for the deflections, which can be repeated over many cycles. The microcantilevers deflect in one direction following oxidation and in the opposite direction upon reduction. The

550 nm deflections were calculated to be commensurate with forces per molecule of

650 pN. The thermal relaxation that characterizes the device’s deflection is consistent with the double bistability associated with the palindromic [3]rotaxane and reflects a metastable contracted state. The use of the cooperative forces generated by these self-assembled, nanometer-scale artificial molecular muscles that are electrically wired to an external power supply constitutes a seminal step toward molecular-machine-based nanoelectromechanical systems (NEMS).

JACS, Vol. 131, No. 11

Golden Metallopolymers with an Active T₁ State via Coordination of Poly(4-vinyl)pyridine to Pentahalophenyl-Gold(I) Precursors

Manal A. Rawashdeh-Omary, Jos

M. L

pez-de-Luzuriaga, Maher D. Rashdan, Oussama Elbjeirami, Miguel Monge, Mar

a Rodr

guez-Castillo and Antonio Laguna

Growth of Oriented Single-Crystalline Rutile TiO₂ Nanorods on Transparent Conducting Substrates for Dye-Sensitized Solar Cells

Bin Liu and Eray S. Aydil

Org. Biomol. Chem., 2009, 7, 1064 - 1067

Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1

David Foley, Patrick Bailey, Myrtani Pieri and David Meredith

Friday, March 20, 2009

Macromol. Chem. Phys. , Vol 210, Iss 5, 2009

Thiyl Radical Generation in Thiol or Disulfide Containing Photosensitive System

Jacques Lalevée, Fabrice Morlet-Savary, Mohamad El Roz, Xavier Allonas, Jean Pierre Fouassier
p 311-319

Biomacromolecules, Vol 10, Iss 3, 2009

Tunable Antimicrobial Polypropylene Surfaces: Simultaneous Attachment of Penicillin (Gram +) and Gentamicin (Gram −)

Nattharika Aumsuwan, Matthew S. McConnell and Marek W. Urban

pp 623–629

Tuesday, February 24, 2009

Langmuir

Vol. 24, Iss. 22, 2008

Adsorption of Well-Defined Fluorine-Containing Polymers onto Poly(tetrafluoroethylene)

Shuko Suzuki, Michael R. Whittaker, Edeline Wentrup-Byrne, Michael J. Monteiro and Lisbeth Grøndahl

pp 13075–13083

Atomic Force Microscopy Investigation of Phage Infection of Bacteria

Evgeniy V. Dubrovin, Alexandr G. Voloshin, Sergey V. Kraevsky, Tatiana E. Ignatyuk, Sergei S. Abramchuk, Igor V. Yaminsky and Sergei G. Ignatov

pp 13068–13074

Nanostructured Films of Amphiphilic Fluorinated Block Copolymers for Fouling Release Application

Elisa Martinelli, Serena Agostini, Giancarlo Galli, Emo Chiellini, Antonella Glisenti, Michala E. Pettitt, Maureen E. Callow, James A. Callow, Katja Graf and Frank W. Bartels

pp 13138–13147

Reversible Supramolecular Functionalization of Surfaces: Terpyridine Ligands as Versatile Building Blocks for Noncovalent Architectures

Claudia Haensch, Manuela Chiper, Christoph Ulbricht, Andreas Winter, Stephanie Hoeppener and Ulrich S. Schubert

pp 12981–12985

Vol. 24, Iss. 23, 2008

Macromolecular Crowding Improves Polymer Encapsulation within Giant Lipid Vesicles

Lisa M. Dominak and Christine D. Keating

pp 13565–13571

Vol. 25, Iss. 1, 2009

A Novel Application of Quaternary Ammonium Compounds as Antibacterial Hybrid Coating on Glass Surfaces

Muhammad Jawwad Saif, Jamil Anwar and Munawar Ali Munawar

pp 377–379

Water Repellency on a Fluorine-Containing Polyurethane Surface: Toward Understanding the Surface Self-Cleaning Effect

Wanling Wu, Qingzeng Zhu, Fengling Qing and Charles C. Han

pp 17–20

Vol. 25, Iss. 2, 2009

Layer-by-Layer Deposition of Polyelectrolyte−Polyelectrolyte Complexes for Multilayer Film Fabrication

Yongmei Guo, Wei Geng and Junqi Sun

pp 1004–1010

Vol. 25, Iss. 3, 2009

Molecular Gradients of Bioinertness Reveal a Mechanistic Difference between Mammalian Cell Adhesion and Bacterial Biofilm Formation

Erik A. Burton, Karen A. Simon, Shuyu Hou, Dacheng Ren and Yan-Yeung Luk

pp 1547–1553

Journal of Polymer Science Part A: Polymer Chemistry

Vol. 46, Iss 23, 2008

Polymer brushes containing sulfonated sugar repeat units: Synthesis, characterization, and in vitro testing of blood coagulation activation
N. Ayres, D. J. Holt, C. F. Jones, L. E. Corum, D. W. Grainger
(p 7713-7724)

Vol. 46, Iss 24, 2008

Synthesis of self-healing supramolecular rubbers from fatty acid derivatives, diethylene triamine, and urea
Damien Montarnal, Philippe Cordier, Corinne Soulié-Ziakovic, François Tournilhac, Ludwik Leibler
(p 7925-7936)
Copolymerization of amino acid and amino ester functionalized norbornenes via living ring-opening metathesis polymerization
Stefano C. G. Biagini, Vernon C. Gibson, Matthew R. Giles, Edward L. Marshall, Michael North
(p 7985-7995)

Vol. 47, Iss 1, 2009

Solid-supported amphiphilic triblock copolymer membranes grafted from gold surface
Ekaterina Rakhmatullina, Alexandre Mantion, Thomas Bürgi, Violeta Malinova, Wolfgang Meier
(p 1-13)

Evaluation of automated synthesis for chain and step-growth polymerizations: Can robots replace the chemists?
Ramiro Rojas, Nicole K. Harris, Karolina Piotrowska, Joachim Kohn
(p 49-58)

Acrylates as termination reagent for the preparation of semi-telechelic polymers made by ring opening metathesis polymerization
Christina Lexer, Robert Saf, Christian Slugovc
(p 299-305)

Vol. 47, Iss 4, 2009

pH and ionic strength responsive polyelectrolyte block copolymer micelles prepared by ring opening metathesis polymerization
Kurt Stubenrauch, Ilja Voets, Gerhard Fritz-Popovski, Gregor Trimmel
(p 1178-1191)

Biomacromolecules, Vol.10, Iss2, 2009

Stimuli-Responsive Polymersomes for Programmed Drug Delivery

Fenghua Meng, Zhiyuan Zhong and Jan Feijen

pp 197–209

Suppression of Protein Adsorption on a Charged Phospholipid Polymer Interface

Yan Xu, Madoka Takai and Kazuhiko Ishihara

pp 267–274

Accounts of Chemical Research, Vol. 41, No. 12.

Induced Helical Backbone Conformations of Self-Organizable Dendronized Polymers

Jonathan G. Rudick and Virgil Percec, pp 1641–1652.

Nanoskiving: A New Method To Produce Arrays of Nanostructures

Qiaobing Xu, Robert M. Rioux, Michael D. Dickey and George M. Whitesides, pp 1566–1577.

Nanoletters, Vol. 9, Issue 1.

Optical and Magnetic Properties of Hexagonal Arrays of Subwavelength Holes in Optically Thin Cobalt Films

G. Ctistis, E. Papaioannou, P. Patoka, J. Gutek, P. Fumagalli and M. Giersig , pp 1–6.

Science, 2009, 323,5913, 530-33

Rapid Membrane Disruption by a Perforin-Like Protein Facilitates Parasite Exit from Host Cells

F. C. Kafsack, Janethe D. O. Pena, Isabelle Coppens, Sandeep Ravindran, John C. Boothroyd, Vern B. Carruthers

Science, 2009, 323, 725-26

Confined Polymers Crystallize
Piet J. Lemstra

Science, 2009, 323, 1030-33

Macroscopic 10-Terabit per Square-Inch Arrays from Block Copolymers with Lateral Order
Soojin Park, Dong Hyun Lee, Ji Xu, Bokyung Kim, Sung Woo Hong, Unyong Jeong, Ting Xu, Thomas P. Russel

Monday, February 23, 2009

Angew. Chem. Int. Ed. 2009, 48, 1030 – 1069

Two-Dimensional Polymers: Just a Dream of SyntheticChemists?
Junji Sakamoto, Jeroen van Heijst, Oleg Lukin, and A. Dieter Schlter

Angew. Chem. Int. Ed. 2009, 48, 1014 – 1017

Ruthenium-Catalyzed Isomerization of TerminalOlefins: Applications to Synthesis
Timothy J. Donohoe, Timothy J. C. ORiordan, and Carla P. Rosa

Angew. Chem. Int. Ed. 2009, 48, 1498 –1500

Selective Fluorescence Labeling of Lipids in Living Cells
Anne B. Neef and Carsten Schultz

Angew. Chem. Int. Ed. 2009, 48, 1422 –1424

Isoprene-Assisted Radical Coupling of (Co)polymers Prepared byCobalt-Mediated Radical Polymerization
Antoine Debuigne, Christine Jrme, and Christophe Detrembleur

Angew. Chem. Int. Ed. 2009, 48, 1798 –1802

Responsive Supramolecular Gels Constructed by Crown Ether BasedMolecular Recognition

Zhishen Ge, Jinming Hu, Feihe Huang, and Shiyong Liu

Org. Biomol. Chem., 2009, 7, 603

Tandem dispersion and killing of bacteria from a biofilm
Steven A. Rogers, Michael Krayer, Jonathan S. Lindsey and Christian Melander

The combined effects of biofilm dispersion with a 2-aminoimidazole–triazole conjugate and bactericidal activity with a photodynamic inactivation agent suggest a novel combination therapy for treating diverse microbial infections.

ACS Chem. Bio.2009, 4, 65-74

Use of Artificial Intelligence in the Design of Small Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs

Artem Cherkasov, Kai Hilpert, Håvard Jenssen, Christopher D. Fjell, Matt Waldbrook, Sarah C. Mullaly, Rudolf Volkmer and Robert E.W. Hancock

Chem. Eur. J. 2009, 15, 1123 – 1133

The Role of Hydrophobicity in the Antimicrobial and Hemolytic Activities of
Polymethacrylate Derivatives
Kenichi Kuroda,*[a] Gregory A. Caputo,*[b] and William F. DeGrado[c]

Chem. Eur. J. 2009, 15, 433 – 439

Comparison of Facially Amphiphilic versus Segregated Monomers in the
Design of Antibacterial Copolymers
Gregory J. Gabriel,[a] Janet A. Maegerlein,[a] Christopher F. Nelson,[b]
Jeffrey M. Dabkowski,[b] Tarik Eren,[a] Klaus Nsslein,[b] and Gregory N. Tew*

Chem. Eur. J. 2009, 15, 28–37

Anion–p Slides for Transmembrane Transport
Jiri Mareda and Stefan Matile*[a]

JACS, 2009, Vol. 131, p.865-870

Reversible Phototuning of the Large Anisotropic Magnetization at the Interface between a Self-Assembled Photochromic Monolayer and Gold

Masayuki Suda, Naoto Kameyama, Aya Ikegami and Yasuaki Einaga

Chem. Soc. Rev., 2009, 38, 495–505

Molecular recognition of bilayer vesicles
Jens Voskuhl and Bart Jan Ravoo*

Bioconjugate Chem. 2009, 20, 71–77

Antibacterial and Antifouling Polymer Brushes Incorporating Antimicrobial
Peptide
Karine Glinel,*,†,‡ Alain M. Jonas,†,§ Thierry Jouenne,‡ Je´roˆme Leprince, Ludovic Galas, and
Wilhelm T. S. Huck*,

J. Mater. Chem., 2009, 19, 60–62

Photomobile polymer materials—various three-dimensional movements†
Munenori Yamada,a Mizuho Kondo,a Ryo Miyasato,a Yumiko Naka,a Jun-ichi Mamiya,a Motoi Kinoshita,a
Atsushi Shishido,a Yanlei Yu,b Christopher J. Barrettc and Tomiki Ikeda*

J. Mater. Chem., 2009, 19, 253–260

Protein adsorbers from surface-grafted copolymers with selective binding
sites
Dongming He, Wei Sun, Thomas Schrader and Mathias Ulbricht

Biochimica et Biophysica Acta

Interaction of an artificial antimicrobial peptide with lipid membrane s
Lanlan Yu, Lin Guo, Jeak Ling Ding, Bow Ho, Si-shen Feng, Jonathan Popplewell,
Marcus Swann , Thorsten Wohland
Biochimica et Biophysica Acta 1788 (2009) 333–344

Fluorescent sterols monitor cell penetrating peptide Pep-1 mediated uptake and
intracellular targeting of cargo protein in living cells
Anca D. Petrescu, Aude Vespa, Huan Huang, Avery L. McIntosh, Friedhelm Schroeder, Ann B. Kier
Biochimica et Biophysica Acta 1788 (2009) 425–441

Lipid domains in bacterial membranes and the action of antimicrobial agents
Richard M. Epand, Raquel F. Epand
Biochimica et Biophysica Acta 1788 (2009) 289–294

Phase diagrams and lipid domains in multicomponent lipid bilayer mixtures
Gerald W. Feigenson
Biochimica et Biophysica Acta 1788 (2009) 47–52

JACS, Vol. 131, No. 6

A Tandem Approach to Photoactivated Olefin Metathesis: Combining a Photoacid Generator with an Acid Activated Catalyst

Benjamin K. Keitz and Robert H. Grubbs

Single Conical Nanopores Displaying pH-Tunable Rectifying Characteristics. Manipulating Ionic Transport With Zwitterionic Polymer Brushes

Basit Yameen, Mubarak Ali, Reinhard Neumann, Wolfgang Ensinger, Wolfgang Knoll and Omar Azzaroni

High Lipophilicity of Perfluoroalkyl Carboxylate and Sulfonate: Implications for Their Membrane Permeability

Ping Jing, Patrick J. Rodgers and Shigeru Amemiya

JACS, Vol. 130, No. 7

In Situ Preparation and Modification of Supported Lipid Layers by Lipid Transfer from Vesicles Studied by QCM-D and TOF-SIMS

Angelika Kunze, Peter Sjovall, Bengt Kasemo and Sofia Svedhem

Catechols as Membrane Anion Transporters

Sofya Kostina Berezin and Jeffery T. Davis

Highly Uniaxial Orientation in Oligo(p-phenylenevinylene) Films Induced During Wet-Coating Process

Takeshi Nishizawa, Hady Kesuma Lim, Keisuke Tajima and Kazuhito Hashimoto

A Light-Gated STOP−GO Molecular Shuttle

Ali Coskun, Douglas C. Friedman, Hao Li, Kaushik Patel, Hussam A. Khatib and J. Fraser Stoddart

ACS Nano, 2008, 2 (12), pp 2519–2525

Enzyme Nanorings

Tsui-Fen Chou†, Christopher So§, Brian R. White†, Jonathan C. T. Carlson†, Mehmet Sarikaya§ and Carston R. Wagner†‡*

We have demonstrated that nanostructures, and in particular nanorings incorporating a homodimeric enzyme, can be prepared by chemically induced self-assembly of dihydrofolate reductase (DHFR)-histidine triad nucleotide binding 1 (Hint1) fusion proteins. The dimensions of the nanorings were found by static light scattering and atomic force microscopy studies to be dependent on the length and composition of the peptide linking the fusion proteins, ranging in size from 10 to 70 nm in diameter and 64 to 740 kDa. The catalytic efficiency of the nanorings was found to be dependent on ring size, thus suggesting that the arrangement of supermolecular assemblies of enzymes may be used to control their catalytic parameters.

ACS Nano, 2009, 3 (1), pp 234–240

Assembly and Functionalization of DNA−Polymer Microcapsules

Francesca Cavalieri†‡, Almar Postma†, Lillian Lee†and Frank Caruso†*

We report the synthesis and characterization of DNA-grafted poly(N-isopropylacrylamide) (PNIPAM) micelles, their assembly into multilayered thin films, and the subsequent generation and poly(ethylene glycol) (PEG) functionalization of DNA−PNIPAM microcapsules. Multilayer films were assembled by sequentially depositing DNA-grafted PNIPAM micelles containing the cDNA sequences polyA₃₀ or polyT₃₀ (i.e., PNIPAM-A₃₀ or PNIPAM-T₃₀). DNA−polymer microcapsules were obtained by the alternate deposition of PNIPAM-A₃₀ and PNIPAM-T₃₀ onto silica particles, followed by removal of the template core. Upon removal of the silica core particle, shrinkage of between 30 and 50% was observed for the microcapsules. The presence of PNIPAM within the DNA−polymer hybrid film reduces the permeability of the microcapsules to macrosolutes (e.g., dextran) compared with microcapsules made solely of DNA. The hydrophobic core of the DNA-grafted PNIPAM micelles was designed to contain alkyne “click” groups, which were exploited to covalently couple azide-bearing low-fouling PEG to the DNA−PNIPAM microcapsules. The combination of hydrophobic and reactive “click” nanodomains, along with the degradability of DNA, offers a multifunctional and versatile DNA−polymer capsule system that is envisioned to find applications in the controlled delivery of therapeutics.

Sunday, February 22, 2009

ACS Nano, 2009, 3 (1), pp 16–20 REVIEW

Impact of Nanotechnology on Drug Delivery

Omid C. Farokhzad†‡* and Robert Langer‡§*

† Laboratory of Nanomedicine and Biomaterials and Department of Anesthesiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115 ‡ MIT−Harvard Center for Cancer Nanotechnology Excellence § Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Nanotechnology is the engineering and manufacturing of materials at the atomic and molecular scale. In its strictest definition from the National Nanotechnology Initiative, nanotechnology refers to structures roughly in the 1−100 nm size regime in at least one dimension. Despite this size restriction, nanotechnology commonly refers to structures that are up to several hundred nanometers in size and that are developed by top-down or bottom-up engineering of individual components. Herein, we focus on the application of nanotechnology to drug delivery and highlight several areas of opportunity where current and emerging nanotechnologies could enable entirely novel classes of therapeutics.

Nature materials volume 8 No 1 pg 15 REVIEW

Physical approaches to biomaterial design

Samir Mitragotri¹ & Joerg Lahann²

The development of biomaterials for drug delivery, tissue engineering and medical diagnostics has traditionally been based on new chemistries. However, there is growing recognition that the physical as well as the chemical properties of materials can regulate biological responses. Here, we review this transition with regard to selected physical properties including size, shape, mechanical properties, surface texture and compartmentalization. In each case, we present examples demonstrating the significance of these properties in biology. We also discuss synthesis methods and biological applications for designer biomaterials, which offer unique physical properties.

Nature materials volume 8 No 2 pg 151

Infection-mimicking materials to program dendritic cells in situ -pp151 - 158

Omar A. Ali, Nathaniel Huebsch, Lan Cao, Glenn Dranoff & David J. Mooney

doi:10.1038/nmat2357

Cancer vaccines developed so far typically rely on cell manipulation techniques in the laboratory followed by re-introduction of the cells into the patient. Now, a polymeric material is shown to program and control the trafficking of immune cellsin situ, resulting in specific and protective anti-tumour properties.

Nature materials volume 8 No 2 - pp144 - 150

Complex and hierarchical micelle architectures from diblock copolymers using living, crystallization-driven polymerizations -pp144 - 150

Torben Gädt, Nga Sze Ieong, Graeme Cambridge, Mitchell A. Winnik & Ian Manners

doi:10.1038/nmat2356

A synthetic tool that uses living polymerizations driven by epitaxial crystallization is shown to create a range of complex micelle architectures made from diblock copolymers. Platelet micelles act as initiators for the formation of scarf-like structures with micellar tassels of controlled length, grown from specific locations

nature materials volume 8 article 1

Polymer chain dynamics and glass transition in athermal polymer/nanoparticle mixtures

Hyunjoon Oh & Peter F. Green

doi:10.1038/nmat2354

Tailoring the properties of polymer nanocomposites—polymers incorporating nanoparticles—is essential to develop biomedical, or even electronic, applications. It is now shown that accurate control of the nanoparticle concentration in nanocomposites prepared from athermal mixtures considerably varies the physical properties with respect to the host polymer.

Saturday, February 21, 2009

chembiochem, 2008, 10,34

How Nature Morphs Peptide Scaffolds into Antibiotics

Elizabeth M. Nolan and Christopher T. Walsh*[a]

mini review

chembiochem, 2009, 10, 230

Design of Cell-Surface-Retained Polymers for Artificial Ligand Display

Ryosuke Kamitani,[b] Kenichi Niikura,*[a] Takaharu Okajima,[c] Yasutaka Matsuo,[a] and Kuniharu Ijiro*[a]

CHECK OUR NEW LITERATURE WEBSITE

Tuesday, March 24, 2009

Monday, March 23, 2009