Nature Biotechnology, January 2008, Volume 26 No 1

Biotech as Bush bows out

Aaron LorenzoFollow-on biologics, changes to the patent system, new rules from the FDA and the prospect of a new party in the White House dominate the policy outlook for biotechs. Aaron Lorenzo reports.

February 2008, Volume 4 Number 2 pp107-109

Cu(I) recognition via cation- and methionine interactions in CusF

Methionine-rich motifs have an important role in copper trafficking factors, including the CusF protein. Here we show that CusF uses a new metal recognition site wherein Cu(I) is tetragonally displaced from a Met₂His ligand plane toward a conserved tryptophan. Spectroscopic studies demonstrate that both thioether ligation and strong cation- interactions with tryptophan stabilize metal binding. This novel active site chemistry affords mechanisms for control of adventitious metal redox and substitution chemistry.


Yi Xue, Anna V Davis, Gurusamy Balakrishnan, Jay P Stasser, Benjamin M Staehlin, Pamela Focia, Thomas G Spiro, James E Penner-Hahn and Thomas V O'Halloran

Biomaterials, Volume 29, Issue 10, Pages 1285-1552 (April 2008)

Behavior of synthetic polymers immobilized on a cell membrane
Pages 1345-1355
Yuji Teramura, Yoshihiro Kaneda, Takahiko Totani and Hiroo Iwata

Surface functionalization of titanium with hyaluronic acid/chitosan polyelectrolyte multilayers and RGD for promoting osteoblast functions and inhibiting bacterial adhesion
Pages 1412-1421
Poh-Hui Chua, Koon-Gee Neoh, En-Tang Kang and Wilson Wang

Engineering of an elastic large muscular vessel wall with pulsatile stimulation in bioreactor
Pages 1464-1472
Zhi C. Xu, Wen J. Zhang, Hong Li, Lei Cui, Lian Cen, Guang D. Zhou, Wei Liu and Yilin Cao

Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG–TAT for drug delivery across the blood–brain barrier
Pages 1509-1517
Lihong Liu, Kun Guo, Jia Lu, Subbu S. Venkatraman, Dan Luo, Kian Chye Ng, Eng-Ang Ling, Shabbir Moochhala and Yi-Yan Yang

Science, VOL 319, ISSUE 5862, PAGES 381-499

Perspectives
MATERIALS SCIENCE: Structural Nanocomposites
Y. Dzenis
pg.419-420

MATERIALS SCIENCE: Adaptive Composites
R. Vaia, and J. Baur
pg. 420-421

Progress in Polymer Science, Volume 33, Issue 2, Pages 167-270

Macromolecular monomers for the synthesis of hydrogel niches and their application in cell encapsulation and tissue engineering
Pages 167-179
Charles R. Nuttelman, Mark A. Rice, Amber E. Rydholm, Chelsea N. Salinas, Darshita N. Shah and Kristi S. Anseth

Multiscale modeling and simulation of polymer nanocomposites
Pages 191-269
Q.H. Zeng, A.B. Yu and G.Q. Lu

Biomaterials, Volume 29, Issue 9, pp. 1139-1284 (March 2008)

Recombinant human collagen for tissue engineered corneal substitutes
Pages 1147-1158
Wenguang Liu, Kimberley Merrett, May Griffith, Per Fagerholm, Subhadra Dravida, Belinda Heyne, Juan C. Scaiano, Mitchell A. Watsky, Naoshi Shinozaki, Neil Lagali, Rejean Munger and Fengfu Li

Biodegradable poly-β-hydroxybutyrate scaffold seeded with Schwann cells to promote spinal cord repair
Pages 1198-1206
Liudmila N. Novikova, Jonas Pettersson, Maria Brohlin, Mikael Wiberg and Lev N. Novikov

Science, VOL 319, ISSUE 5861, PAGES 257-348, 18 January 2008

News of the Week
SCIENTIFIC PUBLISHING: Uncle Sam's Biomedical Archive Wants Your Papers
J. Kaiser
pg.266

News Focus
SCIENCE AND COMMERCE: Gene Tests for Psychiatric Risk Polarize Researchers
J. Couzin
pg. 274-277

News Focus
SCIENCE AND COMMERCE: Hoping for a Glimpse of What's Ahead
J. Couzin
pg. 276-277

Nature Chemical Biology 4, 69-74 (2007)

Discovery and characterization of a marine bacterial SAM-dependent chlorinase

Alessandra S Eustáquio^1,4, Florence Pojer^2,4, Joseph P Noel² and Bradley S Moore^1,3

Macromolecular Rapid Communications 2/2008-22/2007

Molecularly Imprinted Multi-Layer Core-Shell Nanoparticles – A Surface Grafting Approach
Natalia Pérez-Moral, Andrew G. Mayes*

Synthesis of Polyelectrolytes Bearing Phosphorylcholine Moieties
Andreas Reisch, Jean-Claude Voegel, Gero Decher, Pierre Schaaf,* Philippe J. Mésini*

A New Route for the Modification of Halogen End Groups to Amino End-Functionalized
Poly(tert-butyl acrylate)s
Sophie Monge,* Olivia Giani, Elodie Ruiz, Manon Cavalier, Jean-Jacques Robin

Nitroxide-Mediated Radical Polymerization in Microemulsiona
Junpei Wakamatsu, Masahiro Kawasaki, Per B. Zetterlund, Masayoshi Okubo*

Atom Transfer Radical Polymerization of iso-Butyl Methacrylate in Microemulsion
with Cationic and Non-Ionic Emulsifiers
Yasuyuki Kagawa, Masahiro Kawasaki, Per B. Zetterlund, Hideto Minami, Masayoshi Okubo*

JOURNAL OF MOLECULAR RECOGNITION

Review
Molecular imprinting science and technology: a survey
of the literature for the years up to and including 2003
Cameron Alexander, Hakan S. Andersson, Lars I. Andersson, Richard J. Ansell,
Nicole Kirsch, Ian A. Nicholls, John O’Mahony and Michael J. Whitcombe

JOURNAL OF MOLECULAR RECOGNITION
J. Mol. Recognit. 2006; 19: 106–180

Interested in synthetic receptors? Check out this!

New J. Chem., 2008, 32, 94 - 98

Star-shaped heavily fluorinated aromatic sulfurs: stabilization of palladium nanoparticles active as catalysts in cross-coupling reactions

Sandra Niembro, Adelina Vallribera and Marcial Moreno-Mañas

---

Two star-shaped heavily fluorinated compounds have been prepared and used as stabilizers of palladium nanoparticles. These materials are useful and reutilizable catalysts in Mizoroki–Heck, Suzuki and Sonogashira cross-couplings.

New J. Chem., 2008, 32, 21 - 23

Brightly shining nanoparticles: lipophilic perylene bisimides in aqueous phase

Heinz Langhals
The dispersion of lipophilic perylene bisimides down to nanoparticle dimensions opens the aqueous phase to these highly fluorescent, water insoluble materials.

PNAS December 26, 2007 | vol. 104 | no. 52 | 20719-20724

Highly permeable polymeric membranes based on the incorporation of the functional water channel protein Aquaporin Z

Manish Kumar*, Mariusz Grzelakowski{dagger}, Julie Zilles*, Mark Clark*, and Wolfgang Meier

The permeability and solute transport characteristics of amphiphilic triblock-polymer vesicles containing the bacterial water-channel protein Aquaporin Z (AqpZ) were investigated. The vesicles were made of a block copolymer with symmetric poly-(2-methyloxazoline)-poly-(dimethylsiloxane)-poly-(2-methyloxazoline) (PMOXA₁₅-PDMS₁₁₀-PMOXA₁₅) repeat units. Light-scattering measurements on pure polymer vesicles subject to an outwardly directed salt gradient in a stopped-flow apparatus indicated that the polymer vesicles were highly impermeable. However, a large enhancement in water productivity (permeability per unit driving force) of up to 800 times that of pure polymer was observed when AqpZ was incorporated. The activation energy (E_a) of water transport for the protein-polymer vesicles (3.4 kcal/mol) corresponded to that reported for water-channel-mediated water transport in lipid membranes. The solute reflection coefficients of glucose, glycerol, salt, and urea were also calculated, and indicated that these solutes are completely rejected. The productivity of AqpZ-incorporated polymer membranes was at least an order of magnitude larger than values for existing salt-rejecting polymeric membranes. The approach followed here may lead to more productive and sustainable water treatment membranes, whereas the variable levels of permeability obtained with different concentrations of AqpZ may provide a key property for drug delivery applications.

Acc. Chem. Res., 40 (12), 1260–1266

Biocatalytic Reductions: From Lab Curiosity to “First Choice”

Stefaan M. A. De Wildeman, Theo Sonke, Hans E. Schoemaker, and Oliver May

Enzyme-catalyzed reductions have been studied for decades and have been introduced in more than 10 industrial processes for production of various chiral alcohols, α-hydroxy acids and α-amino acids. The earlier hurdle of expensive cofactors was taken by the development of highly efficient cofactor regeneration methods. In addition, the accessible number of suitable dehydrogenases and therefore the versatility of this technology is constantly increasing and currently expanding beyond asymmetric production of alcohols and amino acids. Access to a large set of enzymes for highly selective C=C reductions and reductive amination of ketones for production of chiral secondary amines and the development of improved D-selective amino acid dehydrogenases will fuel the next wave of industrial bioreduction processes.

Macromolecular Chemistry and Physics, Vol 209, Iss 1 (Jan 2008)

Trends in Polymer Science
Polymer Synthesis and Modification by Use of Microwaves
Mareike Bardts, Nina Gonsior, Helmut Ritter
(p 25-31)

Conductive Polymer Electrolytes Derived from Poly(norbornene)s with Pendant Ionic Imidazolium Moieties
Yakov S. Vygodskii, Alexander S. Shaplov, Elena I. Lozinskaya, Konstantin A. Lyssenko, Denis G. Golovanov, Inna A. Malyshkina, Nadejda D. Gavrilova, Michael R. Buchmeiser
(p 40-51)

Journal of Polymer Science Part A: Polymer Chemistry, Vol. 46 Iss. 2 (Jan 2008)

Dendritic macromers for hydrogel formation: Tailored materials for ophthalmic, orthopedic, and biotech applications
Mark W. Grinstaff
(p 383-400)

Specific stimuli-responsive antipolyelectrolyte swelling of amphiphilic gel based on methacryloxyethyl dimethyloctane ammonium bromide
Ling Xu, Maolin Zhai, Ling Huang, Jing Peng, Jiuqiang Li, Genshuan Wei
(p 473-480)

Journal of Polymer Science Part A: Polymer Chemistry, Vol. 46 Iss. 1 (Jan 2008)

Synthesis of achiral PEG-PANI rod-coil block copolymers and their helical superstructures
Lifeng Yan, Wei Tao
(p 12-20)

chembiochem, 2008, 9, 62

A Tunable, Chemoselective, and Moldable Biodegradable Polyester for Cell Scaffolds

Devin G. Barrett and Muhammad N. Yousaf*[a]

organic letters, 2008, 10, 53

A Nucleophilic Fe Catalyst for Transesterifications under Neutral Conditions

Silja Magens, Melanie Ertelt, Anja Jatsch, and Bernd Plietker*


A paper talking about transesterfication

organic letters, 2008, 10, 229

Synthesis of a Nanocar with an Angled Chassis. Toward Circling Movement

Takashi Sasaki,† Andrew J. Osgood,‡ Lawrence B. Alemany,†,§
Kevin F. Kelly,‡,§ and James M. Tour*,†,§

JACS Vol. 129, No. 51 (Dec 26, 2007)

.
Sphingomyelin/Phosphatidylcholine and Cholesterol Interactions Studied by Imaging Mass Spectrometry
Leiliang Zheng, Carolyn M. McQuaw, Andrew G. Ewing, and Nicholas Winograd
pp 15730 - 1573

JACS Vol. 129, No. 50 (Dec 19, 2007)

.
Efficient Quenching of Oligomeric Fluorophores on a DNA Backbone
James N. Wilson, Yin Nah Teo, and Eric T. Kool
pp 15426 - 15427



The Prion Protein is a Combined Zinc and Copper Binding Protein: Zn²⁺ Alters the Distribution of Cu²⁺ Coordination Modes
Eric D. Walter, Daniel J. Stevens, Micah P. Visconte, and Glenn L. Millhauser
pp 15440 - 15441

Mimicry of Antimicrobial Host-Defense Peptides by Random Copolymers
Brendan P. Mowery, Sarah E. Lee, Denis A. Kissounko, Raquel F. Epand, Richard M. Epand, Bernard Weisblum, Shannon S. Stahl, and Samuel H. Gellman
pp 15474 - 15476

Both Water- and Organo-Soluble Supramolecular Polymer Stabilized by Hydrogen-Bonding and Hydrophobic Interactions
Edouard Obert, Mathilde Bellot, Laurent Bouteiller, Florence Andrioletti, Catherine Lehen-Ferrenbach, and François Boué
pp 15601 - 15605



Antimicrobial Activity and Protease Stability of Peptides Containing Fluorinated Amino Acids
He Meng and Krishna Kumar
pp 15615 - 15622

Stepwise Noncovalent Synthesis Leading to Dendrimer-Based Assemblies in Water
Thomas M. Hermans, Maarten A. C Broeren, Nikos Gomopoulos, A. F. Smeijers, Brahim Mezari, Ellen N. M. Van Leeuwen, Matthijn R. J. Vos, Pieter C. M. M. Magusin, Peter A. J. Hilbers, Marcel H. P. Van Genderen, Nico A. J. M. Sommerdijk, George Fytas, and E.W. Meijer
pp 15631 - 15638

Angewandte Chemie International Edition 5/2008 to 44/2007

Angewandte is strange... in some issues there is nothing, and in others you want to post the entire journal.

One-Step Synthesis and Exploratory Chemistry of [5]Dendralene**
Gomotsang Bojase, Alan D. Payne, Anthony C. Willis, and Michael S. Sherburn*
Nice stuff... those are easy to functionalize. I'm thinking ADMET... Naomi, maybe a new SAMP backbone for your proposal.

Understanding Ionic Liquids at the Molecular Level: Facts, Problems, and Controversies
Hermann Weingärtner*
Are Ionic Liquids really worth the hype?

The Next Generation of Shape-Persistant Zeolite Analogues: Covalent Organic Frameworks**
Michael Mastalerz*
and
Hole Control in Microporous Polymers**
Christoph Weder*
Exciting for new materials - making polymers with defined holes... indefinite applications!

Single-Molecule Magnets with Mesomorphic Lamellar Ordering**
Emmanuel Terazzi, Cyril Bourgogne, Richard Welter, Jean-Louis Gallani, Daniel Guillon,
Guillaume Rogez,* and Bertrand Donnio*
For Zoha, Yongping and Raj

Stimuli-Responsive Reversible Transport of Nanoparticles Across
Water/Oil Interfaces**
Erik W. Edwards, Munish Chanana, Dayang Wang,* and Helmuth Möhwald
and
Interplay between Hydrogen Bonding and Macromolecular Architecture Leading to Unusual Phase Behavior in Thermosensitive Microgels**
Martina Keerl, Vytautas Smirnovas, Roland Winter, and Walter Richtering*
New stimuli responsive polymers

Sc(OTf)3-Mediated Silylation of Hydroxy Functional Groups on a Solid Surface: A Catalytic Grafting Method Operating at Room Temperature**
Ye-Rim Yeon, Young Jun Park, Ji-Sung Lee, Jung-Woo Park, Sin-Gun Kang, and Chul-Ho Jun*
New surface functionalization method

i-Motif Formation with Locked Nucleic Acid (LNA)**
Niti Kumar, Jakob T. Nielsen, Souvik Maiti,* and Michael Petersen*
You know DNA and RNA - but did you ever hear about LNA and PNA??

Free-Radical-Based, Specific Desulfurization of Cysteine: A Powerful Advance in the Synthesis of Polypeptides and Glycopolypeptides**
Qian Wan and Samuel J. Danishefsky
Hot stuff for peptide synthesists

Combining Resonant Piezoelectric Micromembranes with Molecularly Imprinted Polymers**
Cédric Ayela,* Fanny Vandevelde, Denis Lagrange, Karsten Haupt,* and Liviu Nicu
The article itself isn't so exciting, but Molecularly Imprinted Polymers are. They are 'synthetic receptors' - maybe we should look into that...

Amplification of Chirality in Dynamic Supramolecular Aggregates
Anja R. A. Palmans and E. W. Meijer*
and
Controlled Bioactive Nanostructures from Self-Assembly of Peptide
Building Blocks**
Yong-beom Lim, Eunji Lee, and Myongsoo Lee*
and
Synthetic Virus-Like Particles from Self-Assembling Coiled-Coil Lipopeptides and Their Use in Antigen Display to the Immune System
Francesca Boato, Richard M. Thomas, Arin Ghasparian, Annabelle Freund-Renard, Kerstin Moehle, and John A. Robinson*
were presented last subgroup

Polymeric Nanoparticles as Imaging Probes for Protein Kinase Activity in Cells
Bernhard Schuster*
for the confocal people

Conjugated Microporous Poly(aryleneethynylene)
Networks**
Jia-Xing Jiang, Fabing Su, Abbie Trewin, Colin D. Wood, Neil L. Campbell,
Hongjun Niu, Calum Dickinson, Alexey Y. Ganin, Matthew J. Rosseinsky,
Yaroslav Z. Khimyak, and Andrew I. Cooper*
More stuff you can do with Poyl(phenyleneethinylens)

Benzoylurea Oligomers: Synthetic Foldamers That Mimic Extended a Helices**
Johanna M. Rodriguez and Andrew D. Hamilton

Learning from Nature: b-Sheet-Mimicking Copolymers Get Organized
Hannah M. König and Andreas F. M. Kilbinger

Antimicrobial Agents and Chemotherapy, Volume 52, Issue 1, p. 65-182, January 2008

In Vitro and In Vivo Antibacterial Activities of DC-159a, a New Fluoroquinolone

p. 65-76
Kazuki Hoshino, Kazue Inoue, Yoichi Murakami, Yuichi Kurosaka, Kenji Namba, Yoshinori Kashimoto, Saori Uoyama, Ryo Okumura, Saito Higuchi, and Tsuyoshi Otani


Comparative Analysis of the Bactericidal Activities of Amphibian Peptide Analogues against Multidrug-Resistant Nosocomial Bacterial Strains

p. 85-91
Maria Luisa Mangoni, Giuseppantonio Maisetta, Mariagrazia Di Luca, Ludovica Marcellini Hercolani Gaddi, Semih Esin, Walter Florio, Franca Lisa Brancatisano, Donatella Barra, Mario Campa, and Giovanna Batoni


Fusarium and Candida albicans Biofilms on Soft Contact Lenses: Model Development, Influence of Lens Type, and Susceptibility to Lens Care Solutions

p. 171-182
Yoshifumi Imamura, Jyotsna Chandra, Pranab K. Mukherjee, Ali Abdul Lattif, Loretta B. Szczotka-Flynn, Eric Pearlman, Jonathan H. Lass, Kerry O'Donnell, and Mahmoud A. Ghannoum

Science, VOL 319, ISSUE 5859, PAGES 11-107, 4 JANUARY 2008

Editorial
Science and God in the Election
D. Kennedy, pg. 12

News of the Week
2008 U.S. BUDGET: Promising Year Ends Badly After Fiscal Showdown Squeezes Science
J. Mervis , pg.18-19

SCIENCE POLICY: Science and the Next U.S. President, pg. 22

DEMOCRAT: Hillary Clinton, pg. 23

DEMOCRAT: John Edwards, pg. 24a-25a

REPUBLICAN: Rudolph Giuliani, pg. 24b-25b

REPUBLICAN: Mike Huckabee, pg. 26a-27a

REPUBLICAN: John McCain, pg. 26b-27b

SCIENCE POLICY: Other Democrats in the Race, pg. 27

DEMOCRAT: Barack Obama, pg. 28a-29a

DEMOCRAT: Bill Richardson, pg. 28b-29b

SCIENCE POLICY: Other Republicans in the Race, pg.29.

REPUBLICAN: Mitt Romney, pg. 30a-31a

REPUBLICAN: Fred Thompson pg.30b-31b

Biomaterials, Volume 29, Issue 8, Pages 955-1138 (March 2008)

Prevention of Staphylococcus epidermidis biofilm formation using a low-temperature processed silver-doped phenyltriethoxysilane sol–gel coating
Pages 963-969
Niall Stobie, Brendan Duffy, Declan E. McCormack, John Colreavy, Martha Hidalgo, Patrick McHale and Steven J. Hinde

Sonication-induced gelation of silk fibroin for cell encapsulation
Pages 1054-1064
Xiaoqin Wang, Jonathan A. Kluge, Gary G. Leisk and David L. Kaplan

Guided tissue remineralisation of partially demineralised human dentine
Pages 1127-1137
Franklin R. Tay and David H. Pashley

Science, VOL 318, ISSUE 5858, PAGES 1829-1941 , 21 December 2007

GALLERIES: SCIENCE AND THE ARTS: Incubating Inspiration?
L. Whiteley
pg. 1871

Education Forum
MENTORING: Linking Student Interests to Science Curricula
L. A. Denofrio, B. Russell, D. Lopatto, and Y. Lu
pg. 1872-1873

Role of Intermolecular Forces in Defining Material Properties of Protein Nanofibrils
T. P. Knowles, A. W. Fitzpatrick, S. Meehan, H. R. Mott, M. Vendruscolo, C. M. Dobson, and M. E. Welland
pg. 1900-1903

Nano Letters, Vol. 7, Iss. 12, December 2007.

Moiré Patterns in Superimposed Nanoporous Thin Films Derived from Block-Copolymer Assemblies

Valeriy Luchnikov, Alexey Kondyurin, Petr Formanek, Hannes Lichte, and Manfred Stamm
pp 3628 - 3632

Biological Templated Synthesis of Water-Soluble Conductive Polymeric Nanowires

Zhongwei Niu, Jie Liu, L. Andrew Lee, Michael A. Bruckman, Donggao Zhao, Goutam Koley, and Qian Wang
pp 3729 - 3733

Nature, Volume 450, Number 7171

Correspondence:

Few women join ranks of Germany's academic élite

p788
Laura Niven

Nature, Volume 450, Number 7173

Photonics: Charge of the light brigade

p1172
The latest study of fluorescence in nanowires shows that it can be controlled by electric fields. This finding suggests the presence of mobile charge carriers, which could be useful for designing nanoelectronic devices.
David J. Nesbitt

Superconductivity without phonons

p1177
P. Monthoux, D. Pines & G. G. Lonzarich

London Daily Mail

How doctors lie on death certificates to hide the true scale of the toll from hospital infections

By Sue Reid

First post of 2008!

Basic idea is that MRSA and resistant clostridium are often not specifically noted as causes of death.