ACS Nano, 2009, 3 (3), pp 673–681

Benzaldehyde-Functionalized Polymer Vesicles

Abstract:

Polymer vesicles with diameters of ca. 100−600 nm and bearing benzaldehyde functionalities within the vesicular walls were constructed through self-assembly of an amphiphilic block copolymer PEO₄₅-b-PVBA₂₆ in water. The reactivity of the benzaldehyde functionalities was verified by cross-linking the polymersomes and also by a one-pot cross-linking and functionalization approach to further render the vesicles fluorescent, each via reductive amination. In vitro studies found these labeled nanostructures to undergo cell association