Nano Lett., 2009, 9 (7), pp 2532–2536

Quantum Dot Light-Emitting Devices with Electroluminescence Tunable over the Entire Visible Spectrum

Polina O. Anikeeva,†,‡ Jonathan E. Halpert,†,§ Moungi G. Bawendi,§
and Vladimir Bulovic´*,‡

Nano Lett., 2009, 9 (7), pp 2589–2599

Neurotoxin Quantum Dot Conjugates Detect Endogenous Targets Expressed in Live Cancer Cells

Rebecca L. Orndorff† and Sandra J. Rosenthal*,†,‡,§,|

Macromolecules 2009, 42, 4941–4945

Reversible “Self-Locked” Micelles from a Zwitterion-Containing Triblock Copolymer†

Joel D. Flores,‡ Xuewei Xu,‡ Nicolas J. Treat,‡ and
Charles L. McCormick*,‡,§

Macromolecules 2009, 42, 5272–5277

Order-Disorder Transition of Nanocomposites: Pd Nanoparticles in Polystyrene-block-Polyisoprene Microdomain Templates

Yue Zhao,†,‡ Kenji Saijo,‡ Mikihito Takenaka,‡ Satoshi Koizumi,† and Takeji Hashimoto*,†,‡

Macromolecules 2009, 42, 5411–5413

Metal-Free “Click” Chemistry: Efficient Polymer Modification via 1,3-Dipolar Cycloaddition of Nitrile Oxides and Alkynes

Ishwar Singh,† Zoya Zarafshani,‡ Jean-Franc-ois Lutz,*,‡ and
Frances Heaney*,†

soft matter, 2009, 5, 2694–2703

Neutron and X-ray scattering for biophysics and biotechnology: examples of self-assembled lipid systems

Thad A. Harroun,*a Norbert Kucerka,b Mu-Ping Niehb and John Katsaras*b

soft matter, 2009, 5, 3047-3053

Thermo-responsive viscoelastic wormlike micelle to elastic hydrogel transition in dual-component systems

Yiyang Lin, Yan Qiao, Yun Yan and Jianbin Huang*

advanced materials, 2009, 21, 1-5

Mesoscopic Network Structure of a Semi-Rigid Polyion Complex Nested in a Polycationic Hydrogel

Zi Liang Wu, Hidemitsu Furukawa, Wei Yang, Jian Ping Gong *

Advanced materials, 2009, 21, 1-9

Advanced Material Strategies for Tissue Engineering Scaffolds

Lisa E. Freed 1 2 *, George C. Engelmayr Jr. 2, Jeffrey T. Borenstein 1, Franklin T. Moutos 3, Farshid Guilak 3

Chem. Commun., 2009, 4390–4392

Optical detection of glucose by CdS quantum dots immobilizedin smart microgels
Weitai Wu, Ting Zhou, Jing Shen and Shuiqin Zhou*

Advanced materials, 2009, 21, 1-5

Dynamic, 3D-Pattern Formation Within Enzyme-Responsive Hydrogels

Karin S. Straley ², Sarah C. Heilshorn ¹

Journal of Materials Chemistry

2009, 19
Reverse thermogelling biodegradable polymer aqueous solutions
Min Kyung Joo, Min Hee Park, Bo Gyu Choi and Byeongmoon Jeong
(33) 5891 - 5905

Multi-stimuli-triggered release of charged dye from smart PEGylated nanogels containing gold nanoparticles to regulate fluorescence signals
Motoi Oishi, Takahito Nakamura, Yuta Jinji, Kiyoto Matsuishi and Yukio Nagasaki
(33) 5909 - 5912

Nature Materials

2009, 8
Review Article
Ionic-liquid materials for the electrochemical challenges of the future
Michel Armand, Frank Endres, Douglas R. MacFarlane, Hiroyuki Ohno & Bruno Scrosati
5621 - 629

Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments
Cole A. DeForest, Brian D. Polizzotti, & Kristi S. Anseth
2659 - 664

Organic conductors: Polymers as one-dimensional metals
Alessandro Troisi
538 - 539

Biomacromolecules

2009, 10 (8)

Hydrogels Cross-Linked by Native Chemical Ligation
Bi-Huang Hu, Jing Su and Phillip B. Messersmith
pp 2194–2200

Polymerizable Vancomycin Derivatives for Bactericidal Biomaterial Surface Modification: Structure−Function Evaluation
McKinley C. Lawson†‡, Richard Shoemaker§, Kevin B. Hoth†, Christopher N. Bowman† and Kristi S. Anseth*
pp 2221–2234

2009, 10 (7)
Stimuli-Sensitive Xanthan Derivatives/N-Isopropylacrylamide Hydrogels: Influence of Cross-Linking Agent on Interpenetrating Polymer Network Properties
Mihaela Hamcerencu†‡§, Jacques Desbrieres*‡, Marcel Popa† and Grard Riess§
pp 1911–1922

Cell-Adhesive Star Polymers Prepared by ATRP
Sidi A. Bencherif†, Haifeng Gao†‡, Abiraman Srinivasan§, Daniel J. Siegwart, Jeffrey O. Hollinger*§, Newell R. Washburn*† and Krzysztof Matyjaszewski*†
pp 1795–1803

Biomaterials

Simultaneous release of multiple molecules from poly(lactide-co-glycolide) nanoparticles assembled onto medical devices
Pages 4889-4897
Catherine T. Lo, Paul R. Van Tassel, W. Mark Saltzman

Zwitterionic carboxybetaine polymer surfaces and their resistance to long-term biofilm formation
Pages 5234-5240
Gang Cheng, Guozhu Li, Hong Xue, Shengfu Chen, James D. Bryers, Shaoyi Jiang

Nature Chemical Biology

Interactive exploration of chemical space with Scaffold Hunter - pp581 - 583

Stefan Wetzel, Karsten Klein, Steffen Renner, Daniel Rauh, Tudor I Oprea, Petra Mutzel & Herbert Waldmann

We describe Scaffold Hunter, a highly interactive computer-based tool for navigation in chemical space that fosters intuitive recognition of complex structural relationships associated with bioactivity. The program reads compound structures and bioactivity data, generates compound scaffolds, correlates them in a hierarchical tree-like arrangement, and annotates them with bioactivity. Brachiation along tree branches from structurally complex to simple scaffolds allows identification of new ligand types. We provide proof of concept for pyruvate kinase.

Nature Chemical Biology

Finding better protein engineering strategies - pp526 - 529

Romas J Kazlauskas & Uwe T Bornscheuer

doi:10.1038/nchembio0809-526

Protein improvement strategies today involve widely varying combinations of rational design with random mutagenesis and screening. To make further progress—defined as making subsequent protein engineering problems easier to solve—protein engineers must critically compare these strategies and eliminate less effective ones.

Science, 324, July 2009, 594

Ultrasmooth Patterned Metals for Plasmonics and Metamaterials
Prashant Nagpal et al,

Angew. Chem. Int. Ed. 2009, 48, 5653 –5656

Soluble Polymeric Dual Sensor for Temperature and pH Value**
Christian Pietsch, Richard Hoogenboom,* and Ulrich S. Schubert

Angew. Chem. Int. Ed. 2009, 48, 5666 –5669

Mechanical Nanosensor Based on FRET within a Thermosome:Damage-Reporting Polymeric Materials
Nico Bruns, Katarzyna Pustelny, Lisa M. Bergeron, Timothy A. Whitehead, andDouglas S. Clark*

Angew. Chem. Int. Ed. 2009, 48, 5930 –5933

Imaging of Catenated, Figure-of-Eight, and Trefoil Knot PolymerRings**
Michel Schappacher and Alain Deffieux*

Journal of Polymer Science A: Polymer Chemistry

The first one is worth a look from gel people thinking about double-network systems. The second is more angled towards the antimicrobial/cpp people, though its usefulness is mixed at best.

Nanostructured polymer composite nanoparticles synthesized in a single step via simultaneous ROMP and ATRP under microemulsion conditions

Postpolymerization modification of poly(pentafluorophenyl methacrylate): Synthesis of a diverse water-soluble polymer library

Angew. Chem. Int. Ed. 2009, 48, 5942 –5945

Synthesis of Well-Defined Hyperbranched Polyamides by Condensation Polymerization of AB2 Monomer through Changed Substituent Effects
Yoshihiro Ohta, Shuichi Fujii, Akihiro Yokoyama, Taniyuki Furuyama, Masanobu Uchiyama,and Tsutomu Yokozawa*

PNAS

The second of these two is really excellent.

Binding-site geometry and flexibility in DC-SIGN demonstrated with surface force measurements

Insertion of short transmembrane helices by the Sec61 translocon

Angew. Chem. Int. Ed. 2009, 48, 6144 –6147

Self-Assembled ABC Triblock Copolymer Double and Triple Helices
John Dupont, Guojun Liu,* Ken-ichi Niihara, Ryuhei Kimoto, and Hiroshi Jinnai

Angew. Chem. Int. Ed. 2009, 48, 5418 – 5429

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities
Alexander V. Kabanov* and Serguei V. Vinogradov

Nature Nanotechnology

Determination of protein structural flexibility by microsecond force spectroscopy

Carbon nanotube tips for atomic force microscopy

Biochimica et Biophysica Acta, ASAP

Oligotryptophan-tagged antimicrobial peptides and the role of the cationic sequence
Adam A. Strömstedt , Mukesh Pasupuleti , Artur Schmidtchen, Martin Malmsten

The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes
Ruthven N.A.H. Lewis, Ronald N. McElhaney

Fungicidal effect of antimicrobial peptide arenicin-1
Cana Park, Dong Gun Lee

The effect of salt and pH on block liposomes studied by cryogenic transmission electron microscopy
Alexandra Zidovska, Kai K. Ewert, Joel Quispe, Bridget Carragher, Clinton S. Potter, Cyrus R. Safinya

chembiochem, 2009, 10, 1527

Proteolysis of Peptide Dendrimers

Peter Sommer, Viviana S. Fluxa, Tamis Darbre, and Jean-Louis Reymond*[a]

ChemBioChem, 2009, 10, 1765

How Can Folded Biopolymers and Synthetic Foldamers Recognize Each Other?


Benoit Baptiste,[b] Frdric Godde,[a] and Ivan Huc*[a]

organic letters, 2009, 11, 2748

Solvophobic Effects in the Self-Assembly of Triangular-Shape Amphiphilic Oligo(phenylene ethynylenes)

Fa´tima Garcı´a, Fa´tima Aparicio, Gustavo Ferna´ndez, and Luis Sa´nchez*

Macromol. Rapid Commun. August 2009

Polymerizable Well-Defined Oligo(thiophene amide)s and their ROMP Block Copolymers (p 1249-1257)
Stefan Hilf, Johannes Klos, Kookheon Char, Heeje Woo, Andreas F. M. Kilbinger

Acc Chem Res August 2009

The current issue is on the chemistry of imaging and there's tons of stuff we should look at, esp. the CPP people:

Two-Photon Probes for Intracellular Free Metal Ions, Acidic Vesicles, And Lipid Rafts in Live Tissues

Lipid-Shelled Vehicles: Engineering for Ultrasound Molecular Imaging and Drug Delivery

Bioresponsive, Cell-Penetrating, and Multimeric MR Contrast Agents

Cell-Penetrating Metal Complex Optical Probes: Targeted and Responsive Systems Based on Lanthanide Luminescence

Antimicrobial Agents and Chemotherapy, August 2009, p. 3538-3540, Vol. 53, No. 8

Synergistic Interaction between Silver Nanoparticles and Membrane-Permeabilizing Antimicrobial Peptides

Silver nanoparticles, as well as antimicrobial peptides (AMPs), can be used to fight infectious diseases. Since AMPs are known to permeabilize bacterial membranes and might therefore help silver nanoparticles to access internal target sites, we investigated their combined activities and showed synergistic effects betweenpolymyxin B and silver nanoparticles for gram-negative bacteria.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3501-3504, Vol. 53, No. 8

Rapid and Reliable Detection of Antimicrobial Peptide Penetration into Gram-Negative Bacteria Based on Fluorescence Quenching

In this paper, we describe a rapid flow cytometry method to identify antimicrobial peptides that are internalized into bacterial cells and differentiate them from those that are membrane active. The method was applied to fluorescently labeled Bac7_1-35and polymyxin B, whose mechanisms of action are, respectively, based on cell penetration and on membrane binding and permeabilization. Identification of peptides with the former mechanism is of considerable interest for the intracellular delivery of membrane-impermeant drugs.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3422-3429, Vol. 53, No. 8

Antibacterial Properties and Mode of Action of a Short Acyl-Lysyl Oligomer

We investigated the potency, selectivity, and mode of action of the oligo-acyl-lysine (OAK) NC₁₂-2β₁₂, which was recently suggested to represent the shortest OAK sequence that retains nonhemolytic antibacterial properties. A growth inhibition assayagainst a panel of 48 bacterial strains confirmed that NC₁₂-2β₁₂ exerted potent activity against gram-positive bacteria while exhibiting negligible hemolysis up to at least 100 times the MIC. Interestingly, NC₁₂-2β₁₂ demonstrated a bacteriostatic mode of action, unlike previously described OAKs that were bactericidal and essentially active against gram-negative bacteria only. The results of various experiments with binding to model phospholipid membranes correlated well with those of the cytotoxicity experiments and provided a plausible explanation for the observed activity profile. Thus, surface plasmon resonance experiments performed with model bilayers revealed high binding affinity to a membrane composition that mimicked the plasma membrane of staphylococci (global affinity constant [K_app], 3.7 x 10⁶ M^–1) and significantly lower affinities to mimics of Escherichia coli or red blood cell cytoplasmic membranes. Additional insertion isotherms and epifluorescence microscopy experiments performed with model Langmuir monolayers mimicking the outer leaflet of plasma membranesdemonstrated the preferential insertion of NC₁₂-2β₁₂ into highly anionic membranes. Finally, we provide mechanistic studies in support of the view that the bacteriostatic effect resulted from a relatively slow process of plasma membrane permeabilization involving discrete leakage of small solutes, such as intracellular ATP. Collectively, the data point to short OAKs as a potential source for new antibacterial compounds that can selectively affect the growth of gram-positive bacteria while circumventing potential adverse effects linked to lytic compounds.

Antimicrobial Agents and Chemotherapy, August 2009, p. 3302-3307, Vol. 53, No. 8

Light-Microscopic Immunocytochemistry for Gentamicin and Its Use for Studying Uptake of the Drug in Kidney

Gentamicin (GM) is a widely used antibiotic but shows renal toxicity. We produced a serum against GM (anti-GM) conjugated to bovine serum albumin with N-(gamma-maleimidobutyryloxy)succinimide. The antiserum was monospecific for GM and did not cross-react with the analog streptomycin, tobramycin, kanamycin, or amikacin. The antiserum also detected glutaraldehyde-fixed GM, and this enabled us to develop an immunocytochemical method for detecting the uptake of GM in rat kidney. Twelve hours after a single intravenous administration of GM, immunocytochemistry revealed that GM accumulated in the S1, S2, and S3 segments of the proximal tubules, as well as in the distal tubules and collecting ducts. By 12 h after injection, the drug was detected in cytoplasmic granules of the proximal tubule cells. However, early (1 h) after injection, drug accumulation was detected in the microvilli of these cells. The distal tubules and collecting ducts contained scattered swollen cells, reminiscent of necrotic cells, in whichboth the nuclei and the cytoplasm reacted strongly with GM. No staining occurred in the kidneys of saline-injected control rats. These results agree with previous studies showing that GM is endocytosed in the proximal tubules and accumulates in lysosomes. Additionally, our results show that GM also accumulates in the distal tubules and collecting ducts. This was achieved by systematically varying the pretreatment conditions—an approach necessary for detecting GM in different subcellular compartments. This approach should be useful for accurately detecting the uptake and toxicity of the antibiotic in different tissues.

Chem. Eur. J. 2009, 15, 7192 – 7202

Preparation of Polyfunctional Arylmagnesium, Arylzinc, and Benzylic Zinc
Reagents by Using Magnesium in the Presence of LiCl

Fabian M. Piller, Albrecht Metzger, Matthias A. Schade, Benjamin A. Haag,
Andrei Gavryushin, and Paul Knochel*[a]

Chem. Eur. J. 2009, 15, 7822 – 7829

Magnetism in Nanoparticles: Beyond the Effect of Particle Size


Davide Peddis, Carla Cannas, Anna Musinu, and Giorgio Piccaluga*[a]

Chem. Soc. Rev., 2009, 38, 2202–2213

Synthetic approaches for the preparation of cyclic polymers


Boyd A. Laurent and Scott M. Grayson*

Bioconjugate Chem. 2009, 20, 1044–1053

Guanidinylated Polyethyleneimine-Polyoxypropylene-Polyoxyethylene
Conjugates as Gene Transfection Agents

Lev Bromberg,† Svetlana Raduyk,‡ T. Alan Hatton,† Angel Concheiro,§ Cosme Rodriguez-Valencia,§ Maite Silva,
and Carmen Alvarez-Lorenzo*,§

Bioconjugate Chem. 2009, 20, 1095–1099

Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As
Potential Carrier for Intracellular Drug Delivery

Ling-Yan Tang,† Yu-Cai Wang,*,‡ Yang Li,† Jin-Zhi Du,‡ and Jun Wang*,†

Bioconjugate Chem. 2009, 20, 1307–1314

Synthesis and Studies on Cell-Penetrating Peptides

Jean-Remi Bertrand,† Claude Malvy,† Tiphanie Auguste,† Ga´bor K. To´th,‡ Orsolya Kiss-Iva´nkovits,‡ Eszter Illye´s,§ Miklo´s Hollo´si,§ Sa´ndor Bottka, and Ilona Laczko´*,

ACS Chemical Biology,4,485-587, 2009

High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model
Terence I. Moy, Annie L. Conery, Jonah Larkins-Ford, Gang Wu, Ralph Mazitschek, Gabriele Casadei, Kim Lewis, Anne E. Carpenter and Frederick M. Ausubel
pp 527–533

Effect of Sequence and Structural Properties on 14-Helical β-Peptide Activity against Candida albicans Planktonic Cells and Biofilms
Amy J. Karlsson, William C. Pomerantz, Keane J. Neilsen, Samuel H. Gellman and Sean P. Palecek
pp 567–579

JACS, 131, 9602-9858, 2009

α-Hydroxyalkyl Heterocycles via Chiral Allylic Boronates: Pd-Catalyzed Borylation Leading to a Formal Enantioselective Isomerization of Allylic Ether and Amine
Stphanie Lessard, Feng Peng and Dennis G. Hall
pp 9612–9613

Structure−activity Relationships among Random Nylon-3 Copolymers That Mimic Antibacterial Host-Defense Peptides
Brendan P. Mowery, Alexandra H. Lindner, Bernard Weisblum, Shannon S. Stahl and Samuel H. Gellman
pp 9735–9745

Free Radical Polymers with Tunable and Selective Bio- and Chemical Degradability
Jos M. J. Paulusse, Roey J. Amir, Richard A. Evans and Craig J. Hawker
pp 9805–9812

JACS, 131, 9860-10334, 2009

A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism
Steven A. Rogers, Robert W. Huigens III and Christian Melander
pp 9868–9869

Three-Dimensional Biomimetic Mineralization of Dense Hydrogel Templates
Gao Liu, Dacheng Zhao, Antoni P. Tomsia, Andrew M. Minor, Xiangyun Song and Eduardo Saiz
pp 9937–9939

JACS, 131, 10336-10794, 2009

Hyperbranched Polymers with a Degree of Branching of 100% Prepared by Catalyst Transfer Suzuki−Miyaura Polycondensation
Weiguo Huang, Linjie Su and Zhishan Bo
pp 10348–10349

Chemoselective Ligation in the Functionalization of Polysaccharide-Based Particles
Tristan T. Beaudette, Joel A. Cohen, Eric M. Bachelder, Kyle E. Broaders, Jessica L. Cohen, Edgar G. Engleman and Jean M. J. Frchet
pp 10360–10361

Star Polymers via Cross-Linking Amphiphilic Macroinitiators by AGET ATRP in Aqueous Media
Wenwen Li and Krzysztof Matyjaszewski
pp 10378–10379

Alternating Ring-Opening Metathesis Copolymerization of Amino Acid Derived Norbornene Monomers Carrying Nonprotected Carboxy and Amino Groups Based on Acid−Base Interaction
Sutthira Sutthasupa, Masashi Shiotsuki, Toshio Masuda and Fumio Sanda
pp 10546–10551

JACS, 131, 10796-11270, 2009

Selective Radical Addition with a Designed Heterobifunctional Halide: A Primary Study toward Sequence-Controlled Polymerization upon Template Effect
Shohei Ida, Takaya Terashima, Makoto Ouchi and Mitsuo Sawamoto
pp 10808–10809

High Resolution Heteronuclear Correlation NMR Spectroscopy of an Antimicrobial Peptide in Aligned Lipid Bilayers: Peptide−Water Interactions at the Water−Bilayer Interface
Riqiang Fu, Eric D. Gordon, Daniel J. Hibbard and Myriam Cotten
pp 10830–10831

Observation of NMR Signals from Proteins Introduced into Living Mammalian Cells by Reversible Membrane Permeabilization Using a Pore-Forming Toxin, Streptolysin O
Shinji Ogino, Satoshi Kubo, Ryo Umemoto, Shuxian Huang, Noritaka Nishida and Ichio Shimada pp 10834–10835

Mesoporous Films and Polymer Brushes Helping Each Other To Modulate Ionic Transport in Nanoconfined Environments. An Interesting Example of Synergism in Functional Hybrid Assemblies
Alejandra Calvo, Basit Yameen, Federico J. Williams, Galo J.A.A. Soler-Illia and Omar Azzaroni pp 10866–10868

Microwave-Assisted Synthesis of Thiophene Fluorophores, Labeling and Multilabeling of Monoclonal Antibodies, and Long Lasting Staining of Fixed Cells
Massimo Zambianchi, Francesca Di Maria, Antonella Cazzato, Giuseppe Gigli, Manuel Piacenza, Fabio Della Sala and Giovanna Barbarella
pp 10892–10900

Directed Assembly of PEGylated-Peptide Coatings for Infection-Resistant Titanium Metal
Xiaojuan Khoo, Paul Hamilton, George A. O’Toole, Brian D. Snyder, Daniel J. Kenan and Mark W. Grinstaff
pp 10992–10997

Toward an Artificial Golgi: Redesigning the Biological Activities of Heparan Sulfate on a Digital Microfluidic Chip
Jeffrey G. Martin, Megha Gupta, Yongmei Xu, Srinivas Akella, Jian Liu, Jonathan S. Dordick and Robert J. Linhardt
pp 11041–11048

Palladium-Catalyzed Coupling of Ammonia with Aryl Chlorides, Bromides, Iodides, and Sulfonates: A General Method for the Preparation of Primary Arylamines
Giang D. Vo and John F. Hartwig
pp 11049–11061