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Tuning Nanoparticle Uptake: Live-Cell Imaging Reveals Two Distinct Endocytosis Mechanisms Mediated by Natural and Artificial EGFR Targeting Ligand Frauke M. Mickler†, Leonhard Möckl†, Nadia Ruthardt†, Manfred Ogris‡, Ernst Wagner‡, and Christoph Bräuchle*† †Department of Chemistry and Center for NanoScience (CeNS) and ‡Department of Pharmacy and Center for NanoScience (CeNS), Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, D-81377 München, Germany