Microwave-Assisted Organic Synthesis and Transformations using Benign Reaction Media
Vivek Polshettiwar and Rajender S. Varma
A nonclassical heating technique using microwaves, termed “Bunsen burner of the 21st century”, is rapidly becoming popular and is dramatically reducing reaction times. The significant outcomes of microwave (MW)-assisted green chemistry endeavors, which have resulted in the development of synthetic protocols for drugs and fine chemicals synthesis that are relatively more sustainable, are summarized. The use of emerging microwave-assisted chemistry techniques in conjunction with greener reaction media is dramatically reducing chemical waste and reaction times in several organic syntheses and chemical transformations. A brief historic account of our own experiences in developing MW-assisted organic transformations, which involve various benign alternatives, such as solid-supported reagents, and greener reaction media, namely, aqueous, ionic liquid, and solvent-free, for the synthesis of various heterocycles, coupling reactions, oxidation–reduction reactions, and some name reactions are described.
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