Antimicrobial Agents and Chemotherapy, Volume 56 No 4 April 2012

Temporal Interplay between Efflux Pumps and Target Mutations in Development of Antibiotic Resistance in Escherichia coli

Renu Singh, Michelle C. Swick, Kimberly R. Ledesma, Zhen Yang, Ming Hu, Lynn Zechiedrich, and Vincent H. Tam

Deciphering the Magainin Resistance Process of Escherichia coli Strains in Light of the Cytosolic Proteome

Simone Maria-Neto, Elizabete de Souza Cândido, Diana Ribas Rodrigues, Daniel Amaro de Sousa, Ezequiel Marcelino da Silva, Lidia Maria Pepe de Moraes, Anselmo de Jesus Otero-Gonzalez, Beatriz Simas Magalhães, Simoni Campos Dias, and Octávio Luiz Franco

Pharmacological Inhibition of the ClpXP Protease Increases Bacterial Susceptibility to Host Cathelicidin Antimicrobial Peptides and Cell Envelope-Active Antibiotics

Shauna M. McGillivray, Dan N. Tran, Nitya S. Ramadoss, John N. Alumasa, Cheryl Y. Okumura, George Sakoulas, Micah M. Vaughn, Dawn X. Zhang, Kenneth C. Keiler, and Victor Nizet

NLRP3 Inflammasome Is a Target for Development of Broad-Spectrum Anti-Infective Drugs

James D. Thacker, Brian J. Balin, Denah M. Appelt, Sihem Sassi-Gaha, Mitali Purohit, Richard F. Rest, and Carol M. Artlett

In Vitro and In Vivo Antimalarial Activities of T-2307, a Novel Arylamidine

Akiko Kimura, Hiroshi Nishikawa, Nobuhiko Nomura, Junichi Mitsuyama, Shinya Fukumoto, Noboru Inoue, and Shin-ichiro Kawazu

In Vitro Potency and In Vivo Efficacy of a Novel Bis-Indole Antimicrobial Compound in Reducing Catheter Colonization

Mohammad D. Mansouri, Timothy J. Opperman, John D. Williams, Charles Stager, and Rabih O. Darouiche